Registration Dossier

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
publication
Title:
Contact allergy and cross reactivity to substituted tiourea compounds.
Author:
Roberts, J.L.and Hanifin
Year:
1980
Bibliographic source:
J.M. Contact dermatitis, 1980; 6: 138-139.

Materials and methods

Study type:
clinical case study
Endpoint addressed:
skin sensitisation
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Seven patients with allergic contact dermatitis to ethylbutylthiourea (EBT) were tested for cross sensitivity to related alkyl-substituted thiourea compounds (including DBTU)
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no data

Method

Type of population:
occupational

Results and discussion

Clinical signs:
Seven patients with allergic contact dermatitis to ethylbutylthiourea (EBT) were tested for cross sensitivity to related alkyl-substituted thiourea compounds.
=> 4 of the EBT-sensitive patients showed a positive reaction to dibutylthiourea.

Applicant's summary and conclusion