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EC number: 203-674-6
CAS number: 109-46-6
No specific study was performed to assess the hydrolysis of 1,3-dibutyl-2-thiourea but it's well recognised that thioureas are stable in aqueous medium. Several data have been used in a "Weight of Evidence" approach in order to confirm this information. The hydrolysis study of DBTU is therefore waived according to section 1.2 of annex XI of REACh regulation EC 1907/2006 as it can be concluded from a weight of evidence that DBTU is hydrolytically stable at environmental temperature and pH.
specific study was performed to assess the hydrolysis of 1,3-dibutyl-2-thiourea
but it's well recognised that thioureas are stable in aqueous
medium. Several data have been used in a "Weight of Evidence" approach
in order to confirm this information.
publications from William H.R. and David G. Walker present the
conclusions of kinetic studies of thiourea derivatives. These studies
have been performed in aqueous media at elevated temperatures. The
authors indicate that this reaction is independent on pH and give rate
constants (k) obtained at various temperatures. Half-life can be
estimated with the following equation: Half-life (t ½) = ln (2) / k
date are given for a temperature of 100°C:
the constant k is comprised between 0.65 x 10-7s and 2.09 x 10-7s.
= 0.65 x 10-7(t ½) = 10 663 802.78 sec = 123 days
k = 2.09 x 10-7(t ½) = 3
316 493.69 sec = 38 days
the constant k is 2.23 x 10-7s.
½) = 3 108 283.32 sec = 36 days
the constant k is 2.5 x 10-7s.
½) = 2 772 588.7 sec. = 32 days
considering its structure, the authors suggest that hydrolysis is
unimportant. Indeed, hydrolysis of dimethythiourea should form
ammonia: from pH 1 to pH 11, no ammonia was detected by their sensitive
tests in reacted solutions of this compound.
stability in aqueous medium is also mentioned in a publication from
Schmidt-Bleek F.et al.which quotes several data obtained on
chemicals by "German Chemical Industry" and "highly experienced research
institutes of the German federal Republic sponsored by the
last, regarding the analytical monitoring performed during ecotox
studies (up to 96 hours), which show that 1,3-dibutyl-2-thiourea
measured concentrations were maintained closed to 100% of the nominal
concentrations, one can consider that hydrolysis of 1,3-dibutyl-2
-thiourea is negligible under environmental conditions.
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