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EC number: 701-259-9 | CAS number: -
Tables of results for plate incorporation and pre-incubation test results are attached as word files
This study was performed to investigate the potential of Fatty acids, tall-oil, epoxidized, 2-ethylhexylesters (ETP) to induce gene mutations in the plate incorporation test (Experiment I) and the pre-incubation test (Experiment II) using the Salmonella typhimurium strains TA 1535, TA 1537, TA 98, and TA 100, and the Escherichia coli strain WP2 uvrA.
The assay was performed in two independent experiments both with and without liver microsomal activation.
Each concentration, including the controls, was tested in triplicate.
Fatty acids, tall-oil, epoxidized, 2-ethylhexylesters (ETP)
was tested at the following concentrations:
Experiment I: 3; 10; 33; 100; 333; 1000; 2500; and 5000 µg/plate
Experiment II: 33; 100; 333; 1000; 2500; and 5000 µg/plate
The plates incubated with the test item showed normal background growth up to 5000 µg/plate with and without metabolic activation in both independent experiments.
No toxic effects, evident as a reduction in the number of revertants, occurred in the test groups with and without metabolic activation.
No substantial increase in revertant colony numbers of any of the five tester strains was observed following treatment with Fatty acids, tall-oil, epoxidized, 2-ethylhexylesters (ETP) at any dose level, neither in the presence nor absence of metabolic activation (S9 mix). There was also no tendency for higher mutation rates with increasing concentrations in the range below the generally acknowledged border of biological relevance.
Appropriate reference mutagens were used as positive controls and showed a distinct increase of induced revertant colonies. Relevant historical control data were also presented in the sudy report but are not reproduced in this summary.
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