Registration Dossier

Administrative data

basic toxicokinetics
Type of information:
other: Theoreitcal assessment
Adequacy of study:
weight of evidence

Data source

Materials and methods

Objective of study:
Test guideline
no guideline followed
Principles of method if other than guideline:
Theoretical assessmnet of toxicokinetic properties
GLP compliance:

Results and discussion

Applicant's summary and conclusion


Based on the common metabolism and enzymatic description, it is considered justifiable to apply results from the epoxidised oil ETP to Fatty acids, C12-20 and C12-20-unsatd., 2-ethylhexyl esters for the derivation of critical endpoints.

The read across justification for a non toxic epoxidised natural ester and an unsaturated natural ester is proposed through the low toxicity of a central epoxidised unsaturated ester compared to a central unsaturated alkene.

The toxicity profile of the 2-ethyl hexyl ester structural component which is identical for both the EDT epoxy and the Fatty acids, C12-20 and C12-20-unsatd., 2-ethylhexyl esters was demonstrated as having low toxicity from the EDT data.