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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1973
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: No raw data are included (calculated LD values only). No data on the number of animals per dose group. No data on clinical signs or gross pathology.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1973

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Mice were exposed to five concentrations of test substance on five consecutive days. Mortalities were recorded daily during the dosing and 10 days after the last dose. Body weight was measured before the first dose and 24h after the 5th dose.
GLP compliance:
no
Test type:
other: no details on study design
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
not specified

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
Animals were exposed on 5 consecutive days and observed for 10 days after the last dose.
Doses:
125; 250; 600; 1000; 2000 mg/kg
No. of animals per sex per dose:
no data
Control animals:
not specified
Statistics:
no

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 030 mg/kg bw

Any other information on results incl. tables

The mortalities are given in the table below, number of animals is not specified. No difference in body weight gain was observed between the groups from the beginning of the study to day 6, when the weights were recorded.

 

Dose (mg/kg)

Day 1

2000

100%

1000

40%

500

0%

250

0%

125

0%

Derived LD50 (mg/kg)

1030 ± 165*

* 24h after the 1stdose

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
The oral LD50 is 1030 ± 165 mg/kg.
Executive summary:

The acute oral toxicity of menadione was tested in mice. The LD50 is 1030 ± 165 mg/kg, as determined 24h after the first dose.