Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1962
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 962
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- see Principles of method
- Deviations:
- yes
- Remarks:
- important data supplied but less extensive as later work, not relevant for conclusions from experimental results
- Principles of method if other than guideline:
- Details as described by Smyth, H.; Carpenter, C.; Well, C.; Pozzani, U.; Striegel, J., Range-Finding Toxicity Data, List VI American Industrial Hygiene Association Journal 23(2) 95-107 (1962)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Test material form:
- solid
- Details on test material:
- not reported
Constituent 1
- Specific details on test material used for the study:
- no data available
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- 2.5-3.5 kg/animal
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 h exposure + 14 d observation period
- No. of animals per sex per dose:
- 4
- Control animals:
- yes
- Details on study design:
- important data supplied but less extensive as later work, not relevant for conclusions from experimental results
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 570 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Executive summary:
In a study similar to later guidelline the test item exhbited a LD50 dermal, rabbit of 570 mg/kg bw
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