Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Acute Toxicity: oral
Some information in this page has been claimed confidential.
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1962
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 962
Materials and methods
- Principles of method if other than guideline:
- As described in Smyth, H.; Carpenter, C.; Well, C.; Pozzani, U.; Striegel, J., Range-Finding Toxicity Data, List VI American Industrial Hygiene Association Journal 23(2) 95-107 (1962)
- GLP compliance:
- no
- Remarks:
- presumably no accepted guideline existing at that time
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Test material form:
- solid
- Details on test material:
- not reported
Constituent 1
- Specific details on test material used for the study:
- no data available
Test animals
- Species:
- rat
- Strain:
- Wistar
- Remarks:
- Carworth-Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- 4-5 weeks old, 90-120 / animal , Rockland rat diet, complete, reared in own premisees of Mellon Institute of Industrial Research, Pittsburgh
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- intubation
- Doses:
- logarithmic factor 2x
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- 14 d observation period
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD0
- Effect level:
- >= 1 540 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no
- Clinical signs:
- no effect observed
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- no effect in rats, LC0 rat oral >= 1540 mg/kg bw (highest concentration tested)
- Executive summary:
In a study of Smyth, H.; Carpenter, C.; Well, C.; Pozzani, U.; Striegel, J., Range-Finding Toxicity Data, List VI American Industrial Hygiene Association Journal 23(2) 95-107 (1962), no effect was observed in rats, yielding a LC0 rat oral >= 1540 mg/kg bw for the highest concentration tested
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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