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Short-term toxicity to aquatic invertebrates

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ADONA toxicity was studied in two invertebrate species, Daphnia magna and Chironomus riparius. ADONA is water soluble. Analytical monitoring in both studies showed that measured concentrations were stable and in agreement with nominal concentrations during the 96-hour test period, therefore the effect parameters referenced the nominal concentrations which had been corrected for the proportion of the active ingredient. The 48-hour EC50 of ADONA to D. magna was > 100 mg/L (active ingredient) based on no observed immobilization at the highest concentration tested. The 96-hour LC50 of ADONA to C .riparius larvae was > 1000 mg/L (active ingredient) based on no observed mortality and no observed behavioral effects at the highest concentration tested. While C. riparius larvae dwell in sediment, the test substance was dosed into the water column and only a thin layer of sand was present at the bottom of the test vessels. Therefore, this study should be considered an aquatic toxicology test.

Both studies were performed in accordance with internationally-accepted test guidelines and Good Laboratory Practice (GLP) standards. Therefore, the studies are reliable without restrictions and the results suitable for purposes of Risk Assessment, Classification & Labeling, and PBT Analysis. The D. magna study was conducted according to the OECD guideline 202, and the C. riparius study protocol was based on ASTM Standard E729-96 and US EPA Test method 100.2. Thus, ADONA is classified as not acutely toxic to aquatic invertebrates in accordance with the classification system of the Globally Harmonized System (GHS) and Not Classified - conclusive but not sufficient for classification in accordance with the EU classification, labelling and packaging system (CLP).