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Physical & Chemical properties

Density

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Reference
Endpoint:
relative density
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Principles of method if other than guideline:
Determination of the sedimentation constant allows calculation of the density using the Svedberg equation. This has been performed in peer reviewed articles and summarised in Creighton "Proteins: structure and molecular properties" (1993).
Type of method:
other: Calculation of the density using the Svedberg equation.
Type:
density
Density:
> 1.33 - < 1.42 g/cm³
Temp.:
20 °C
Remarks on result:
other: density range for 20 different proteins from different protein-families
Type:
relative density
Density:
> 1.33 - < 1.42 other: Relative density is dimensionless.
Remarks on result:
other: Relative density is dimensionless.

Creighton reviews density data retrieved from structurally and fuctionally different proteins. They all have densities in the range between 1.32 and 1.42 g/ml. We ascertain that Thermomycolin also has a density in this range since it is a protein, even though not experimentally determined.

Conclusions:
Thermomycolin is a protein and therefore it can be assumed that this has density within the range 1.33 - 1.42 g/ml.
Executive summary:

Densities have been determined for a wide range of different proteins. This analysis showed that the density range is between 1.32 and 1.42 g/ml. Since Thermomycolin is a protein, we conclude that this protein also has density within this range.

Description of key information

The densities have been determined for a wide range of different proteins. This analysis showed that the density range is between 1.33 to 1.42 g/ml. Since Thermomycolin is a protein, it is assumed that it also has density within this range.

Key value for chemical safety assessment

Relative density at 20C:
1.37

Additional information

We report the average value of 1.37 g/ml as a representative value of the density. However, it should be noted that the uncertainty is expected to be in the order of +/- 0.05 g/ml.