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Ecotoxicological information

Short-term toxicity to fish

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Reference
Endpoint:
short-term toxicity to fish
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
REPORTING FORMAT FOR THE ANALOGUE APPROACH : Please see attached Read Across supporting document in Section 13 which includes the following:
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
3. ANALOGUE APPROACH JUSTIFICATION
4. DATA MATRIX
Reason / purpose:
read-across source
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Key result
Duration:
96 h
Dose descriptor:
NOEC
Effect conc.:
100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Duration:
96 h
Dose descriptor:
LC100
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Details on results:
No mortality was observed for an analogous substance.
Conclusions:
Based on read across to an analogue substance the 96 hour LC50 was predicted to be >100 mg/L and the 96
hour NOEC was predicted to be 100 mg/L.
Executive summary:

A read across approach was used to determine the LC50 and NOEC of Solvent Red 19 T ( 1-({2-methyl-4-[(2-methylphenyl)diazenyl]phenyl}diazenyl)-N-tridecylnaphthalen-2-amine). The results from an analogue substance with the same structure, but where the tridecyl group has been replaced with a 2 -ethyl hexyl group were >100mg/L (LC50) and 100mg/L for NOEC. The materials are structural similarity, have similar solubility and QSAR software (EPISUITE ECOSAR) predicts that both materials will show no acute aquatic toxicity at saturation. The LC50 and NOEC of the target substance are predicted to be >100mg/L and 100mg/L respectively.

Description of key information

Based on read across to an analogue substance, the 96 hour LC50 was predicted to be >100 mg/L and the 96 hour NOEC was 100 mg/L.

Key value for chemical safety assessment

LC50 for freshwater fish:
100 mg/L

Additional information

A read across approach was used to determine the LC50 and NOEC of Solvent Red 19 T ( 1-({2-methyl-4-[(2-methylphenyl)diazenyl]phenyl}diazenyl)-N-tridecylnaphthalen-2-amine). The results from an analogue substance with the same structure, but where the tridecyl group has been replaced with a 2 -ethyl hexyl group were >100mg/L (LC50) and 100mg/L for NOEC. The materials are structural similarity, have similar solubility and QSAR software (EPISUITE ECOSAR) predicts that both materials will show no acute aquatic toxicity at saturation. The LC50 and NOEC of the target substance are predicted to be >100mg/L and 100mg/L respectively.