Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 222-775-6 | CAS number: 3609-96-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Based on the available studies dipotassium hydrogen citrate can be stated as non-genotoxic.
Link to relevant study records
- Endpoint:
- in vitro cytogenicity / micronucleus study
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The study was well documented and meets generally accepted scientific principles, but was not conducted in compliance with GLP.
- GLP compliance:
- no
- Type of assay:
- in vitro mammalian cell micronucleus test
- Species / strain / cell type:
- lymphocytes: human peripheral lymphocytes
- Metabolic activation:
- without
- Test concentrations with justification for top dose:
- nominal concentrations: 50, 100, 200, 3000 µg/ml
- Vehicle / solvent:
- water
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- mitomycin C
- Details on test system and experimental conditions:
- Application: in water
Incubation duration: 72 h
Exposure duration: 24 h and 48 h
Actin polymerisation inhibitor cytochalasin B (cytoB) 5.2 µg/ml was added after 48 hours.
STAIN (for cytogenetic assays): Giesma
replications: duplicate cultures (two donors: healthy non-smokers, 27 years, 1 male, 1 female)
number of cells evaluated: 1000 binucleate cells/donor (micronucleus analysis), 500/donor, 2 donors
determination of cytotoxicity: Cytokinesis-Block Proliferation Index - Statistics:
- difference in % abnormal cells: z-test; dose-response relationship: correlation and regression coefficient
- Key result
- Species / strain:
- lymphocytes: human peripheral lymphocytes
- Metabolic activation:
- without
- Genotoxicity:
- positive
- Remarks:
- at a concentration of 3000 µg/mL
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- at a concentration of 3000 µg/mL
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not examined
- Positive controls validity:
- valid
- Conclusions:
- Citric acid significantly increased the frequency of chromosomal aberrations, Sister chromatid exchanges (except 50 µg/mL for 24 h) and micronucleus in all treatment groups as compared to their negative controls without changing the pH of the medium. Citric acid induced five types of structural aberration in lymphocytes.
It is concluded that the test substance is positive for the induction of micronuclei in cultured human lymphocytes under the conditions of this study. - Endpoint:
- in vitro cytogenicity / micronucleus study
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Potassium citrate salts are known to show a very high solubility in water and dissociate rapidly.
Potassium in known to be non-toxic. The toxicity is determined by the citrate moiety of the substance.
Because of that a read-across to citric acid is suitable for the determination of the toxicity. - Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The study was well documented and meets generally accepted scientific principles, but was not conducted in compliance with GLP.
- GLP compliance:
- no
- Type of assay:
- in vitro mammalian cell micronucleus test
- Species / strain / cell type:
- lymphocytes: human peripheral lymphocytes
- Metabolic activation:
- without
- Test concentrations with justification for top dose:
- nominal concentrations: 50, 100, 200, 3000 µg/ml
- Vehicle / solvent:
- water
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- mitomycin C
- Details on test system and experimental conditions:
- Application: in water
Incubation duration: 72 h
Exposure duration: 24 h and 48 h
Actin polymerisation inhibitor cytochalasin B (cytoB) 5.2 µg/ml was added after 48 hours.
STAIN (for cytogenetic assays): Giesma
replications: duplicate cultures (two donors: healthy non-smokers, 27 years, 1 male, 1 female)
number of cells evaluated: 1000 binucleate cells/donor (micronucleus analysis), 500/donor, 2 donors
determination of cytotoxicity: Cytokinesis-Block Proliferation Index - Statistics:
- difference in % abnormal cells: z-test; dose-response relationship: correlation and regression coefficient
- Key result
- Species / strain:
- lymphocytes: human peripheral lymphocytes
- Metabolic activation:
- without
- Genotoxicity:
- positive
- Remarks:
- at a concentration of 3000 µg/mL
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- at a concentration of 3000 µg/mL
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not examined
- Positive controls validity:
- valid
- Conclusions:
- Citric acid significantly increased the frequency of chromosomal aberrations, Sister chromatid exchanges (except 50 µg/mL for 24 h) and micronucleus in all treatment groups as compared to their negative controls without changing the pH of the medium. Citric acid induced five types of structural aberration in lymphocytes.
It is concluded that the test substance is positive for the induction of micronuclei in cultured human lymphocytes under the conditions of this study. - Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Version / remarks:
- The study was well documented and meets generally accepted scientific principles, but was not conducted in compliance with GLP. Test was performed with several substances, positive results were obtained with some substances tested without performing a positive test with a reference substance.
- GLP compliance:
- no
- Type of assay:
- bacterial reverse mutation assay
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Species / strain / cell type:
- S. typhimurium, other: TA92
- Species / strain / cell type:
- S. typhimurium, other: TA94
- Metabolic activation:
- with and without
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- other: L cysteine monohydrochloride
- Details on test system and experimental conditions:
- - Preincubation period: 20 min
- Exposure duration: 48 hours
- Fixation time (start of exposure up to fixation or harvest of cells): 48 hours
duplicate plates were used - Evaluation criteria:
- The result was considered positive if the number of colonies found was twice the number in the control (exposed to the appropriate solvent or untreated). If no reasonable dose-response was found, the experiment was repeated using different doses.
- Key result
- Species / strain:
- S. typhimurium TA 1535
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- valid
- Remarks:
- Test was performed with several substances, positive results were obtained with some substances tested without performing a positive test with a reference substance.
- Key result
- Species / strain:
- S. typhimurium TA 1537
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- valid
- Remarks:
- Test was performed with several substances, positive results were obtained with some substances tested without performing a positive test with a reference substance.
- Key result
- Species / strain:
- S. typhimurium TA 98
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- valid
- Remarks:
- Test was performed with several substances, positive results were obtained with some substances tested without performing a positive test with a reference substance.
- Key result
- Species / strain:
- S. typhimurium TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- valid
- Remarks:
- Test was performed with several substances, positive results were obtained with some substances tested without performing a positive test with a reference substance.
- Key result
- Species / strain:
- S. typhimurium, other: TA92
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- valid
- Remarks:
- Test was performed with several substances, positive results were obtained with some substances tested without performing a positive test with a reference substance.
- Key result
- Species / strain:
- S. typhimurium, other: TA94
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- valid
- Remarks:
- Test was performed with several substances, positive results were obtained with some substances tested without performing a positive test with a reference substance.
- Conclusions:
- The test substance showed negative results on all strains with and without metabolic activation.
No increase in revertant colonies was detected. It was concluded that citric acid is not mutagenic under the conditions of this test. - Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Potassium citrate salts are known to show a very high solubility in water and dissociate rapidly.
Potassium in known to be non-toxic. The toxicity is determined by the citrate moiety of the substance.
Because of that a read-across to citric acid is suitable for the determination of the toxicity. - Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Version / remarks:
- The study was well documented and meets generally accepted scientific principles, but was not conducted in compliance with GLP. Test was performed with several substances, positive results were obtained with some substances tested without performing a positive test with a reference substance.
- GLP compliance:
- no
- Type of assay:
- bacterial reverse mutation assay
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Species / strain / cell type:
- S. typhimurium, other: TA92
- Species / strain / cell type:
- S. typhimurium, other: TA94
- Metabolic activation:
- with and without
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- other: L cysteine monohydrochloride
- Details on test system and experimental conditions:
- - Preincubation period: 20 min
- Exposure duration: 48 hours
- Fixation time (start of exposure up to fixation or harvest of cells): 48 hours
duplicate plates were used - Evaluation criteria:
- The result was considered positive if the number of colonies found was twice the number in the control (exposed to the appropriate solvent or untreated). If no reasonable dose-response was found, the experiment was repeated using different doses.
- Key result
- Species / strain:
- S. typhimurium TA 1535
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- valid
- Remarks:
- Test was performed with several substances, positive results were obtained with some substances tested without performing a positive test with a reference substance.
- Key result
- Species / strain:
- S. typhimurium TA 1537
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- valid
- Remarks:
- Test was performed with several substances, positive results were obtained with some substances tested without performing a positive test with a reference substance.
- Key result
- Species / strain:
- S. typhimurium TA 98
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- valid
- Remarks:
- Test was performed with several substances, positive results were obtained with some substances tested without performing a positive test with a reference substance.
- Key result
- Species / strain:
- S. typhimurium TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- valid
- Remarks:
- Test was performed with several substances, positive results were obtained with some substances tested without performing a positive test with a reference substance.
- Key result
- Species / strain:
- S. typhimurium, other: TA92
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- valid
- Remarks:
- Test was performed with several substances, positive results were obtained with some substances tested without performing a positive test with a reference substance.
- Key result
- Species / strain:
- S. typhimurium, other: TA94
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- valid
- Remarks:
- Test was performed with several substances, positive results were obtained with some substances tested without performing a positive test with a reference substance.
- Conclusions:
- The test substance showed negative results on all strains with and without metabolic activation.
No increase in revertant colonies was detected. It was concluded that citric acid and its soluble salts are not mutagenic under the conditions of this test.
Referenceopen allclose all
The chromosome aberrations in cultured human lymphocytes treated with citric acid
Test substance | Treatment | Structural Aberrations |
Numerical Aberrations
|
Abnormal cell ± SE (%) |
CA/cell ± SE |
||||||
|
Period (h) |
Dose (µg/mL) |
scu |
ctb |
dic |
csb |
cte |
p |
er |
|
|
Negative control |
24 | 0 | 2 | - | - | - | - | - | - | 2.50 ± 0.70 |
0.025 ± 0.01 |
Positive control |
24 |
0.1 |
18 |
25 |
7 |
3 |
12 |
3 |
- |
30.00 ± 3.24 |
0.325 ± 0.03 |
Citric acid |
24 |
50 |
15 |
4 |
5 |
1 |
- |
1 |
1 |
12.50 ± 2.34* |
0.135 ± 0.02* |
Citric acid |
24 |
100 |
25 |
5 |
7 |
1 |
- |
5 |
- |
19.00 ± 2.77* |
0.190 ± 0.03* |
Citric acid | 24 | 200 | 35 | 5 | 10 | - | - | 5 | - | 20.00 ± 2.83* | 0.250 ± 0.03* |
Citric acid | 24 | 3000 | - | - | - | - | - | - | - | toxic | toxic |
Negative control | 48 | 0 | 3 | 1 | - | - | - | - | - | 2.00 ± 0.98 | 0.020 ± 0.01 |
Positive control | 48 | 0.1 | 42 | 7 | 6 | - | 31 | 3 | - | 34.00 ± 3.35 | 0.430 ± 0.035 |
Citric acid | 48 | 50 | 34 | 2 | 2 | - | - | 1 | - | 19.00 ± 2.77* | 0.070 ± 0.03* |
Citric acid | 48 | 100 | 27 | 9 | - | - | 1 | 1 | - | 18.50 ± 2.75* | 0.100 ± 0.03* |
Citric acid | 48 | 200 | 30 | 2 | 3 | 1 | 1 | 4 | - | 18.50 ± 2.75* | 0.105 ± 0.03* |
Citric acid | 48 | 3000 | - | - | - | - | - | - | - | toxic | toxic |
Scu, Sister chromatid union; ctb, chromatid break; dic, dicentric; csb, chromosome break; cte, chromatid exchange; p, polyploidy; er, endoreduplication; CA/cell, (Chromosome aberrations/cell)
200 Metaphases were scored for each treatment
*Significant from the control P\0.001 (z test)
Induction of micronuclei in cultured human lymphocytes treated with citric acid
Test substance | Treatment | Distribution of BN cells according to the no. of MN | MN(%) |
CBPI |
||||
|
Period (h) |
Dose (µg/mL) |
(1) |
(2) |
(3) |
(4) |
|
|
Negative control |
48 |
0 |
6 |
0 |
0 |
0 |
0.30 ± 0.12 |
1.84 ± 0.30 |
Positive control |
48 |
0.1 |
220 |
20 |
0 |
0 |
13.0 ± 0.75 |
1.30 ± 0.25 |
Citric acid |
48 |
50 |
33 |
0 |
0 |
0 |
1.65 ± 0.28* |
1.43 ± 0.27 |
Citric acid |
48 |
100 |
45 |
1 |
0 |
0 |
2.35 ± 0.34* |
1.41 ± 0.26 |
Citric acid |
48 |
200 |
48 |
0 |
0 |
1 |
2.60 ± 0.36* |
1.34 ± 0.26 |
Citric acid |
48 |
3000 |
- |
- |
- |
- |
toxic |
toxic |
BN, Binucleate; MN, Micronucleus; CBPI, Cytokinesis-block proliferation index
*Significant from the control P\0.001 (z-test)
The chromosome aberrations in cultured human lymphocytes treated with citric acid
Test substance | Treatment | Structural Aberrations |
Numerical Aberrations
|
Abnormal cell ± SE (%) |
CA/cell ± SE |
||||||
|
Period (h) |
Dose (µg/mL) |
scu |
ctb |
dic |
csb |
cte |
p |
er |
|
|
Negative control |
24 | 0 | 2 | - | - | - | - | - | - | 2.50 ± 0.70 |
0.025 ± 0.01 |
Positive control |
24 |
0.1 |
18 |
25 |
7 |
3 |
12 |
3 |
- |
30.00 ± 3.24 |
0.325 ± 0.03 |
Citric acid |
24 |
50 |
15 |
4 |
5 |
1 |
- |
1 |
1 |
12.50 ± 2.34* |
0.135 ± 0.02* |
Citric acid |
24 |
100 |
25 |
5 |
7 |
1 |
- |
5 |
- |
19.00 ± 2.77* |
0.190 ± 0.03* |
Citric acid | 24 | 200 | 35 | 5 | 10 | - | - | 5 | - | 20.00 ± 2.83* | 0.250 ± 0.03* |
Citric acid | 24 | 3000 | - | - | - | - | - | - | - | toxic | toxic |
Negative control | 48 | 0 | 3 | 1 | - | - | - | - | - | 2.00 ± 0.98 | 0.020 ± 0.01 |
Positive control | 48 | 0.1 | 42 | 7 | 6 | - | 31 | 3 | - | 34.00 ± 3.35 | 0.430 ± 0.035 |
Citric acid | 48 | 50 | 34 | 2 | 2 | - | - | 1 | - | 19.00 ± 2.77* | 0.070 ± 0.03* |
Citric acid | 48 | 100 | 27 | 9 | - | - | 1 | 1 | - | 18.50 ± 2.75* | 0.100 ± 0.03* |
Citric acid | 48 | 200 | 30 | 2 | 3 | 1 | 1 | 4 | - | 18.50 ± 2.75* | 0.105 ± 0.03* |
Citric acid | 48 | 3000 | - | - | - | - | - | - | - | toxic | toxic |
Scu, Sister chromatid union; ctb, chromatid break; dic, dicentric; csb, chromosome break; cte, chromatid exchange; p, polyploidy; er, endoreduplication; CA/cell, (Chromosome aberrations/cell)
200 Metaphases were scored for each treatment
*Significant from the control P\0.001 (z test)
Induction of micronuclei in cultured human lymphocytes treated with citric acid
Test substance | Treatment | Distribution of BN cells according to the no. of MN | MN(%) |
CBPI |
||||
|
Period (h) |
Dose (µg/mL) |
(1) |
(2) |
(3) |
(4) |
|
|
Negative control |
48 |
0 |
6 |
0 |
0 |
0 |
0.30 ± 0.12 |
1.84 ± 0.30 |
Positive control |
48 |
0.1 |
220 |
20 |
0 |
0 |
13.0 ± 0.75 |
1.30 ± 0.25 |
Citric acid |
48 |
50 |
33 |
0 |
0 |
0 |
1.65 ± 0.28* |
1.43 ± 0.27 |
Citric acid |
48 |
100 |
45 |
1 |
0 |
0 |
2.35 ± 0.34* |
1.41 ± 0.26 |
Citric acid |
48 |
200 |
48 |
0 |
0 |
1 |
2.60 ± 0.36* |
1.34 ± 0.26 |
Citric acid |
48 |
3000 |
- |
- |
- |
- |
toxic |
toxic |
BN, Binucleate; MN, Micronucleus; CBPI, Cytokinesis-block proliferation index
*Significant from the control P\0.001 (z-test)
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.