Registration Dossier
Registration Dossier
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EC number: 686-241-8 | CAS number: 81058-27-7
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19 December 2016 - 07 July 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 112 (Dissociation Constants in Water)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7370 (Dissociation constants in water)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- - Batch n°: M16FB2273
- Analytical purity: 101.7% (w/w)
- Expiration date: 12 September 2017
- Storage condition: at room temperature - Dissociating properties:
- no
- Remarks:
- The test item does not contain ionisable groups. No pKa values could be calculated.
- Conclusions:
- JNJ-42808389-AAA (T003421) has no pKa values for acidic and basic groups in the logarithm range of 1 – 14.
Reference
The test item does not contain ionisable groups. No pKavalues could be calculated.
Description of key information
The calculation method was applied in a GLP study (K1, Ciric, 2017) as a preliminary test to determine the dissociation constant. Since the test item does not contain ionisable groups, no pKa could be calculated.
Key value for chemical safety assessment
Additional information
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