Registration Dossier
Registration Dossier
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EC number: 411-150-5 | CAS number: 29617-66-1 L-2-CHLOROPROPIONIC ACID; L-2-CHLORPROPIONSÄURE
Eye irritation
Administrative data
- Endpoint:
- eye irritation, other
- Remarks:
- other: Human data referenced
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The source is peer reviewed.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 980
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No additional information is given on the guideline followed or the method employed.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-chloropropionic acid
- EC Number:
- 209-952-3
- EC Name:
- 2-chloropropionic acid
- Cas Number:
- 598-78-7
- Molecular formula:
- C3H5ClO2
- IUPAC Name:
- 2-chloropropanoic acid
- Details on test material:
- The substance in the cited reference is 2-Chloropropionic acid, the racemate of L-2-Chloropropionic acid. The physical properties of optical enantiomers are not distinguishable and with regard to physical properties they are considered equivalent. The corrosivity of a substance is often related to the pH, which is also independant of chirality.
No details on the purity or source of the 2-chloropropionic acid are given in the reference.
Constituent 1
Test animals / tissue source
- Species:
- other: Human observations
- Strain:
- other: Not applicable
- Details on test animals or tissues and environmental conditions:
- Not applicable
Test system
- Vehicle:
- not specified
- Controls:
- other: No additional data presented
- Amount / concentration applied:
- No additional data presented
- Duration of treatment / exposure:
- No additional data presented
- Observation period (in vivo):
- No additional data presented
- Number of animals or in vitro replicates:
- Not applicable
- Details on study design:
- No additional data presented
Results and discussion
In vivo
Results
- Basis:
- other: Human observation
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- No additional data presented
- Other effects:
- No additional data presented
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- other: Corrosive
- Remarks:
- Criteria used for interpretation of results: not specified
- Conclusions:
- This reference states that "toxicity studies indicate that the substance to be corrosive to eye and skin".
- Executive summary:
No information on the guideline followed or the method employed is given in this source.
The information presented from this source constitutes an assessment of available human and animal data.
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