Registration Dossier
Registration Dossier
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EC number: 411-150-5 | CAS number: 29617-66-1 L-2-CHLOROPROPIONIC ACID; L-2-CHLORPROPIONSÄURE
Eye irritation
Administrative data
- Endpoint:
- eye irritation, other
- Remarks:
- other: Human data referenced
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The source is peer reviewed.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 980
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No additional information is given on the guideline followed or the method employed.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-chloropropionic acid
- EC Number:
- 209-952-3
- EC Name:
- 2-chloropropionic acid
- Cas Number:
- 598-78-7
- Molecular formula:
- C3H5ClO2
- IUPAC Name:
- 2-chloropropanoic acid
- Details on test material:
- The substance in the cited reference is 2-Chloropropionic acid, the racemate of L-2-Chloropropionic acid. The physical properties of optical enantiomers are not distinguishable and with regard to physical properties they are considered equivalent. The corrosivity of a substance is often related to the pH, which is also independant of chirality.
No details on the purity or source of the 2-chloropropionic acid are given in the reference.
Constituent 1
Test animals / tissue source
- Species:
- other: Human observations
- Strain:
- other: Not applicable
- Details on test animals or tissues and environmental conditions:
- Not applicable
Test system
- Vehicle:
- not specified
- Controls:
- other: No additional data presented
- Amount / concentration applied:
- No additional data presented
- Duration of treatment / exposure:
- No additional data presented
- Observation period (in vivo):
- No additional data presented
- Number of animals or in vitro replicates:
- Not applicable
- Details on study design:
- No additional data presented
Results and discussion
In vivo
Results
- Basis:
- other: Human observation
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- No additional data presented
- Other effects:
- No additional data presented
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- other: Corrosive
- Remarks:
- Criteria used for interpretation of results: not specified
- Conclusions:
- This reference states that "toxicity studies indicate that the substance to be corrosive to eye and skin".
- Executive summary:
No information on the guideline followed or the method employed is given in this source.
The information presented from this source constitutes an assessment of available human and animal data.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
