Registration Dossier
Registration Dossier
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EC number: 414-810-0 | CAS number: - A-88820.605
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 08 June - 15 September, 1994
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: done under GLP and OECD method
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Version / remarks:
- Directive 92/69/EEC
- GLP compliance:
- yes
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- A mixture of: bis(1S,2S,4S)-(1-benzyl-4-tert-butoxycarboxamido-2-hydroxy-5-phenyl)pentylammonium succinate; isopropyl alcohol
- EC Number:
- 414-810-0
- EC Name:
- A mixture of: bis(1S,2S,4S)-(1-benzyl-4-tert-butoxycarboxamido-2-hydroxy-5-phenyl)pentylammonium succinate; isopropyl alcohol
- Cas Number:
- 144163-85-9
- Molecular formula:
- Empirical formula: C25H35N2O5
- IUPAC Name:
- butanedioic acid; propan-2-ol; bis(tert-butyl N-[(4R)-5-amino-4-hydroxy-1,6-diphenylhexan-2-yl]carbamate)
Constituent 1
Study design
- Analytical method:
- other: Spectrophotometric 225nm - 325nm.
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- 0.47
- Temp.:
- 21 °C
- pH:
- >= 5.33 - <= 6.02
- Remarks on result:
- other: no pH specified
- Remarks:
- no pH specified
Any other information on results incl. tables
Aqueous phase conc ranged from 110.28 to 323.18µg/ml with pH values of 5.33 - 6.02.
Octanol phase conc ranged from 499.57 to 543.13µg/ml
Applicant's summary and conclusion
- Conclusions:
- The partition coefficient has been determined to be log Pow 0.47 at 21°C
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