Registration Dossier
Registration Dossier
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EC number: 820-225-5 | CAS number: 101747-77-7
Endpoint summary
Administrative data
Description of key information
Source substance Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (CAS 4259 -15 -8): GLP, similar to OECD Guideline 406, Klimisch 2, guinea pig maximisation test, not skin sensitising
Source substance Phosphorodithioic acid, mixed O,O-bis(1,3 -dimethylbutyl and iso-Pr) esters, zinc salts (CAS 84605 -29 -8): GLP, similar to OECD Guideline 406, Klimisch 2, Buehler test, not skin sensitising
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The source substance Zinc bis[O,O-bis(2-ethylhexyl)] bis(dithiophosphate) (CAS 4259 -15 -8) was tested in a Magnusson-Kligman Guinea Pig maximization test similar to OECD Guideline 406. 20 Dunkin-Hartley strain albino Guinea Pigs were treated with 5.0 % w/v test substance. Scores of zero in all test animals were obtained at all time points examined. The test material does not appear to be a sensitiser in the albino guinea pig (Costello 1982).
The source substance Phosphorodithioic acid, mixed O,O-bis(1,3 -dimethylbutyl and iso-Pr) esters, zinc salts (CAS 84605 -29 -8) was tested in a study similar to OECD Guideline 406 (Buehler assay) according to GLP. The test item was not sensitising (Morris 1997).
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Based on the results for the source substances (no adverse effect observed) the registered substance does not have to be classified according to Regulation (EC) No 1272/2008.
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