Registration Dossier
Registration Dossier
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EC number: 820-225-5 | CAS number: 101747-77-7
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- other: expert statement
- Adequacy of study:
- key study
- Study period:
- 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: An extensive assessment of the toxicokinetic behaviour of the registered substance was performed, taking into account the chemical structure, the available physico-chemical and toxicological data.
Data source
Reference
- Reference Type:
- other: expert statement
- Title:
- Toxicokinetic Statement for Phosphorodithioic acid, mixed O,O- bis(iso-Bu and iso-Pr and pentyl) esters, zinc salts (CAS 101747-77-7)
- Author:
- Chemservice GmbH
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
- Objective of study:
- absorption
- distribution
- excretion
- metabolism
- toxicokinetics
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- An extensive assessment of the toxicokinetic behaviour of the registered substance was performed, taking into account the chemical structure, the available physico-chemical and toxicological data.
- GLP compliance:
- no
Test material
- Reference substance name:
- Zinc, O,O-mixed (iso-Bu), (iso-Pr), (pentyl) phosphorodithioate
- EC Number:
- 820-225-5
- Cas Number:
- 101747-77-7
- Molecular formula:
- C12-20H28-44O4P2S4Zn
- IUPAC Name:
- Zinc, O,O-mixed (iso-Bu), (iso-Pr), (pentyl) phosphorodithioate
- Test material form:
- liquid
Constituent 1
Administration / exposure
- Route of administration:
- other: all relevant routes of administration are discussed in the expert statement
Results and discussion
Main ADME resultsopen allclose all
- Type:
- absorption
- Results:
- The absorption rate of the substance is assumed to be 100 % via the oral, dermal and inhalation route
- Type:
- distribution
- Results:
- The substance is not expected to be distributed widely throughout the body.
- Type:
- metabolism
- Results:
- Transport between cells through cell membranes might be possible.
- Type:
- excretion
- Results:
- The substance is expected to be mainly excreted via the bile since it is amphipathic (containing both polar and nonpolar regions) and has a high molecular weight.
Applicant's summary and conclusion
- Executive summary:
The absorption rate of the substance is assumed to be 100 % via the oral, dermal and inhalation route. The substance is not expected to be distributed widely throughout the body. Transport between cells through cell membranes might be possible. The substance is expected to be mainly excreted via the bile since it is amphipathic (containing both polar and nonpolar regions) and has a high molecular weight. For more details please refer to attached expert statement in section 13.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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