Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 820-225-5 | CAS number: 101747-77-7
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Source substance Phosphorodithioic acid, mixed O,O-bis(1,3 -dimethylbutyl and iso-Pr) esters, zinc salts (CAS 84605 -29 -8):
A study was performed under GLP to assess the effect of the test material on the reproduction of the freshwater invertebrate Daphnia magna over a 21-day period. The method followed that described in the OECD Guidelines for Testing of Chemicals No 211 (1998) "Daphnia magna, Reproduction Test".
The measured concentrations of the test substance differed by greater than 20% from the start of some exposure periods to the end, and therefore time-weighted means were calculated for each of the concentrations. The 21 day IC50s for neonate production, adult daphnid length and adult daphnid weight were > 0.8 mg/L based on nominal loading rates and >0.53 mg/L based on measured concentrations. The NOECs were 0.4 mg/L nominal (0.26 mg/L measured) for reproduction and 0.8 mg/L nominal (0.53 mg/L measured) for both daphnid length and daphnid weight, the latter being the highest level tested. The LOECs were 0.8 mg/L nominal for reproduction and >0.8 mg/L nominal for daphnid length and weight. Measured concentrations were calculated using the time weighted mean method.
For CSA the measured reproduction-NOEC was choosen as the lowest value.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- NOEC
- Effect concentration:
- 0.26 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
