Registration Dossier
Registration Dossier
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EC number: 701-475-3 | CAS number: -
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Justification for type of information:
- At physiological pH, all lithium borates dissociate and release boric acid and lithium ions as a result of relevant transformation pathways. It will the boric acid component of the substances which will drive the mammalian toxicity endpoints. Variations in the structure (trigonal vs tetrahedral) between the substances are not expected to lead to any changes in corrosivity. In order to minimise animal testing, only one substance in the category was tested, dilithium tetraborate. For all other substances in the category, read-across is proposed.
Data source
Materials and methods
Test material
- Reference substance name:
- Dilithium tetraborate
- EC Number:
- 234-514-3
- EC Name:
- Dilithium tetraborate
- Cas Number:
- 12007-60-2
- Molecular formula:
- B4Li2O7
- IUPAC Name:
- dilithium tetraborate
- Test material form:
- solid: bulk
Constituent 1
Results and discussion
In vitro
Resultsopen allclose all
- Irritation / corrosion parameter:
- % tissue viability
- Run / experiment:
- 3 minute
- Value:
- 93
- Vehicle controls validity:
- not applicable
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: not corrosive
- Irritation / corrosion parameter:
- % tissue viability
- Run / experiment:
- 1 hour
- Value:
- 99
- Vehicle controls validity:
- not applicable
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: not corrosive
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- An OECD 431 study was conducted on dilithium tetraborate and found to be non-corrosive. The UVCB-Reaction products of boric acid and lithium hydroxide is also expected to be non-corrosive.
- Executive summary:
An OECD 431 study was conducted on dilithium tetraborate and found to be non-corrosive. Variations in the structure (trigonal vs tetrahedral) between the substances are not expected to lead to any changes in corrosivity as at physiological pH, all the substances dissociate to provide the same common compounds. All substances in the category do not meet CLP criteria for classification as skin irritants.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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