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basic toxicokinetics in vitro / ex vivo
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Composition 0
Objective of study:
other: Assessment of toxicokinetic behaviour
according to
other: Assessment of degradation products
GLP compliance:
Test material information:
Composition 1
Metabolites identified:

Testing has been performed to confirm the degradation of the substance in diluted solutions in water and it is confirmed that in common with the range of organo-titanium complexes of this nature, there will be rapid degradation (30 minutes) with reversion back to starting materials.


These abiotic degradation products have been identified as:




Propylene glycol

Ethylene glycol

Description of key information

Key value for chemical safety assessment

Bioaccumulation potential:
low bioaccumulation potential

Additional information

If swallowed, the substance will quickly hydrolyse to titanium dioxide, triisopropanolamine, propan-2-ol and ethylene glycol. None of these substances are classified as hazardous and although some pH effects from contact with the amine may result in local irritation, this has not been reported from testing. 


The substance is a viscous liquid with minimal risk of inhalation. If on contact with skin, it is likely that there will be exposure to the degradation products; none of these are considered harmful to the skin.


From public documents, the organic degradation products will themselves be readily metabolised if ingested and there is little evidence that the titanium dioxide will be absorbed. 


For the IUCLD endpoints, a read-across titanate has been cited for some of the endpoints, but other references have also been added.