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Environmental fate & pathways

Hydrolysis

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Reference
Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study
Reference:
Composition 0
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
Principles of method if other than guideline:
Initial observations showed rapid degradation in minutes in diluted form
Only performed at 'natural' unbuffered pH 4.4; it is known that pH does not influence the rate of degradation of these highly unstable substances
The volatiles could be detected by analyzing the evaporates from the hydrolyzed The Test Substance by GC chromatograms.
The TIPA content in The Test Sample was very small, therefore, analysing the DEG, EG and PG content degraded from the test substance would indicate the hydrolysis, which was measured by comparing the peak area in GC chromatograms.
GLP compliance:
no
Remarks:
The hydrolysis rate is too fast and rigorous guideline test is not possible.
Test material information:
Composition 1
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Supplier: Borica Co., Ltd.
- Lot number: 000534P
- Expiration date of the lot/batch: 2018-Mar-04
- CAS number: 68784-47-4
Radiolabelling:
no
Analytical monitoring:
yes
Duration:
30 min
pH:
4.4
Temp.:
25 °C
Initial conc. measured:
ca. 0.1 g/L
Number of replicates:
2
Preliminary study:
The diluent could be further diluted till 1:1000 in DI water and the appearance observed become cloudy in 30 minutes. The observation was done in duplicate to confirm the hydrolysis status.
Transformation products:
yes
No.:
#1
Reference substance:
Composition 1
No.:
#2
Reference substance:
Composition 1
No.:
#3
Reference substance:
Composition 1
No.:
#4
Reference substance:
Composition 1
No.:
#5
Reference substance:
Composition 1
Details on hydrolysis and appearance of transformation product(s):
Cloudy appearance on dilution in water as titanium dioxide precipitated out
pH:
4.4
Temp.:
25 °C
Half-life:
<= 30 min
Validity criteria fulfilled:
not applicable
Conclusions:
The target substance degradeed rapidly when diluted in water, with formation of titanium dioxide as a precipitate within minutes. Half-life not possible to measure, but considered to be less than 30 minutes.

The recorded degradation products are titanium dioxide, propan-2-ol, triisopropanolamine, diethylene glycol and ethylene glycol. The organic products are known to biodegrade readily.

Description of key information

Key value for chemical safety assessment

Half-life for hydrolysis:
30 min
at the temperature of:
25 °C

Additional information

The recorded hydrolyisis products include inorganic part and organic parts. The inorganic part is titanium dioxide. The organic parts are ethylene glycol, diethylene glycol, triisopropanolamine and 2 -propanol. The organic products are known to biodegrade readily.