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EC number: 254-104-8 | CAS number: 38725-13-2
Table 1 Results : IVIS
Relative Standard Deviation IVIS
Positive ControlDMF undiluted
This GLP compliant in vitro study was performed to assess the corneal damage potential of Triisononylamine by quantitative measurements of changes in opacity and permeability in a bovine cornea according to OECD 437 Guideline method.
Bovine corneas were used. They were collected from slaughtered cattle that were between 12 and 60 months old. The test item Triisononylamine was brought onto the cornea of a bovine eye which had been previously incubated with cMEM without phenol red at 32 ± 1 °C for 1 hour and whose opacity had been measured. The test item was incubated on the cornea for 10 minutes at 32 ± 1 °C. After removal of the test item and 2 hours post-incubation, opacity and permeability values were measured.
Hank’s Balanced Salt Solution (HBSS) was used as negative control. The negative control showed no irritating effect on the cornea and the calculated IVIS (In Vitro Irritancy Score) is 1.05.
Dimethylformamide (DMF) undiluted was used as positive control. The positive control induced serious eye damage on the cornea and was within two standard deviations of the current historical mean. The calculated IVIS was 72.16.
Under the conditions of this study, the test item Triisononylamine showed no effects on the cornea of the bovine eye. The calculated IVIS was 0.55. According to CLP criteria, a substance with an IVIS ≤ 3 requires no classification for eye irritation or serious eye damage.
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