Bos taurus, milk, pasteurized, homogenized, skimmed, fermented, spray-dried

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

other: expert statement

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a (Q)SAR model, with limited documentation / justification, but validity of model and reliability of prediction considered adequate based on a generally acknowledged source

Justification for type of information:

The logPow values referred to in this expert statement were predicted using EPI Suite™ v4.11, KOWWIN v1.68 (US EPA) and XLOGP3-AA method (Kim et. al., 2015).

Reason / purpose for cross-reference:

reference to other study

Reason / purpose for cross-reference:

reference to other study

Qualifier:

according to guideline

Guideline:

other: EPI Suite™ v4.11, KOWWIN v1.68

Qualifier:

according to guideline

Guideline:

other: XLOGP3-AA method

Principles of method if other than guideline:

The partition coefficient was assessed based on available data on experimental/calculated logPow for its constituents.

Type of method:

other: expert statement based on experimental/calculated data

Type:

log Pow

Remarks on result:

other: see field details on results

Details on results:

Bos taurus, milk, fermented, spray-dried (EC 917-734-0) is a multi-constituent substance consisting mainly of lactose (40 %), different proteins (34 %), water (8 %), raw ash (8 %) and lactic acid (3 %) (see section 1.4 analytical information).

Available logPow data of components
- Lactose:
Read-Across via Trehalose (a,a-D-Trehalose; CAS 99-20-7): -3.77 (Mazzobre et. al., 2005)
Predicted logPow: -5.03 (EPI Suite™ v4.11, KOWWIN v1.68, US EPA, 2018)
(note that Lactose is exempted from REACH registration requirements according to REACH Annex IV (substances included in Annex IV, as sufficient information is known about these substances that they are considered to cause minimum risk because of their intrinsic properties) and can thus be considered to have non-critical properties)

- Lactic acid:
Predicted log Pow -0.7 (XLOGP3-AA method, Kim et. al., 2015)

The main components of the proteins in Bos taurus, milk, fermented, spray-dried (EC 917-734-0) are caseine (80%), serum albumines, beta-lactoglobulines, immunoglobulines and lactalbumines. The following values give an indication that the logPow of these type of proteins should be low:
- Casein:
Predicted logPow -7.1 (XLOGP3-AA method, Kim et. al., 2015)

- Beta-lactoglobulines:
Predicted log Pow -2.4 (XLOGP3-AA method, Kim et. al., 2015)

The logPow does not need to be determined for inorganic constituents.

Conclusions:

The available log Pow values of the constituents of Bos taurus, milk, fermented, spray-dried (EC 917-734-0) are in the range of -0.7 to -7.1 and thus below 0.

Executive summary:

The partition coefficient of Bos taurus, milk, fermented, spray-dried (EC 917-734-0) is assessed based on available data on experimental/calculated logPow for its constituents. The available log Pow values of the constituents are in the range of -0.7 to -7.1 and thus below 0.

Description of key information

The partition coefficient of Bos taurus, milk, fermented, spray-dried (EC 917-734-0) is assessed based on available data on experimental/calculated logPow for its constituents. The available log Pow values of the constituents are in the range of -0.7 to -7.1 and thus below 0.

Key value for chemical safety assessment

Log Kow (Log Pow):

0

at the temperature of:

25 °C

Additional information

The partition coefficient of Bos taurus, milk, fermented, spray-dried (EC 917-734-0) is assessed based on available data on experimental/calculated logPow for its constituents. The available log Pow values of the constituents are in the range of -0.7 to -7.1 and thus below 0.