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Physical & Chemical properties

Solubility in organic solvents / fat solubility

Administrative data

Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
no data
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Insufficient documentation for an assessment of reliability.
Cross-referenceopen allclose all
Reason / purpose:
reference to same study
Reason / purpose:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
no data
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Details on test material:
- Name of test material (as cited in study report): JNJ-559728-AAA (T001250)
- Physical state: solid (powder)
- Appearance: White powder
Specific details on test material used for the study:
no data available

Results and discussion

Solubility in organic solvents / fat solubilityopen allclose all
Medium:
methanol
Solubility:
2.5 other: g/100 mL solution
Medium:
ethanol
Solubility:
1.6 other: g/100 mL solution
Medium:
isopropanol
Solubility:
1 other: g/100 mL solution
Medium:
other: dichloromethane
Solubility:
23 other: g/100 mL solution
Medium:
other: 2-propanone
Solubility:
3.7 other: g/100 mL solution
Medium:
ethyl acetate
Solubility:
2.8 other: g/100 mL solution
Medium:
other: 1,1'-oxybisethane
Solubility:
0.8 other: g/100 mL solution
Medium:
other: hexane
Solubility:
0.084 other: g/100 mL solution
Medium:
other: methylbenzene
Solubility:
3.9 other: g/100 mL solution
Medium:
dimethylformamide
Solubility:
6.7 other: g/100 mL solution
Details on results:
no data

Any other information on results incl. tables

Table 1 Solubility of the T001250 at room temperature

 Solvent  Concentration in g/100 mL solution
 tetrahydrofuran  8.2
 4 -methyl-2-pentanone  2
 sulfinylbismethane 4.8
 2 -butanone 3.7
 N,N-dimethylacetamide  8.1
 2,2'-oxybispropane  0.35

Applicant's summary and conclusion

Executive summary:

Not applicable