Esterification products of salicylic acid and C13-(branched) alcohols

Melting point / freezing point

Administrative data

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

5/1/2018 to 21/5/2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2018

Report date:

2018

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Version / remarks:

27 July 1995

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Other quality assurance:

ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)

Type of method:

differential scanning calorimetry

Test material

Test material information

Constituent 1

Reference substance name:

tridecyl 2-hydroxybenzoate

EC Number:

947-975-7

Molecular formula:

C20H32O3

IUPAC Name:

tridecyl 2-hydroxybenzoate

Specific details on test material used for the study:

Test Item
Identification: Dermol TDSA
Appearance: Colourless to pale yellow clear liquid
Batch: P7202
Purity/Composition: UVCB
Test item storage: At room temperature
Stable under storage conditions until: 11 November 2021 (expiry date)
Additional information
Test Facility test item number: 209078/A
Purity/Composition correction factor: No correction factor required
Test item handling: No specific handling conditions required
Molecular structure: Not indicated
Molecular formula: C20H32O3
Molecular weight: 320
Test Item Characterization
The Sponsor provided to the Test Facility documentation of the identity, purity, composition, and stability for the test item(s). A Certificate of Analysis or equivalent document was provided to the Test Facility and is presented in Appendix 2.

Results and discussion

Melting / freezing point

Key result

Melting / freezing pt.:

< 193 K

Atm. press.:

ca. 1 013 hPa

Any other information on results incl. tables

Preliminary test

The TGA curve of the test item is shown inFigure 1. Starting at 300°C, the weight of the sample decreased significantly. At 356°C, the sample weight had decreased by 25%.

After the experiment it was observed that the test item was evaporated from the sample container.

Main study

The DSC curve obtained with Experiment 1 is shown inFigure 2. During cooling, no effects were observed (results are archived in the raw data). An endothermic peak was observed starting at 250°C. The endothermic effect was probably obtained due to reaction and/or decomposition of the test item.

After the experiment, a yellow residue remained in the sample container (original colour:Colourless). The change of the colour indicated reaction and/or decomposition of the test item. 

An additional investigation of the melting temperature of the test item was performed placing two subsamples of the test item for 23 hours at -19.5 ± 0.6°C and at -83.6 ± 1.7°C respectively. It was observed after storage that the test item was a liquid (≤ ‑15°C freezer) and a viscous liquid (< -80°C freezer). According to this it was concluded that the melting temperature of the test item is < -80°C (< 193K).

Applicant's summary and conclusion

Conclusions:

The melting and boiling temperature of Dermol TDSA were tested by DSC.
The melting temperature of the test item was < -80°C (< 193K) at 1013 hPa, under the conditions of the test and applying a storage experiment in the freezer.
Reaction and/or decomposition of the test item was observed during DSC experiment at temperatures of > 250°C (> 523K). Boiling of the test item was not observed below the temperature at which reaction and/or decomposition started. Based on this, the test item has no boiling temperature.

Executive summary:

The melting and boiling temperature of Dermol TDSA were tested by DSC.

The melting temperature of the test item was < -80°C (< 193K) at 1013 hPa, under the conditions of the test and applying a storage experiment in the freezer.

Reaction and/or decomposition of the test item was observed during DSC experiment at temperatures of > 250°C (> 523K).  Boiling of the test item was not observed below the temperature at which reaction and/or decomposition started.  Based on this, the test item has no boiling temperature.

In this guideline (OECD 102) study, [conducted with GLP certification], the melting point of the test substance (EC 243-214 -1) was found to be <193 K at 1013 hPa.