Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Endpoint summary
Administrative data
Description of key information
Short-term EC50 values for Fructose-1,6-Diphosphate, raw: Glucose anaerobically fermented by Saccharomyces cerevisiae, concentrated, phosphorylated (EC no. 944-754-7) are available for two trophic levels of the aquatic freshwater compartment (aquatic invertebrates, algae).
Growth inhibition study aquatic algae (Desmodesmus subspicatus) (OECD 201):
ErC50(72h): >119 mg/l measured concentration
NOErC (72 h): 119 mg/l measured concentration
Short term toxicity on invertebrates (Daphnia magna) (OECD 202):
EC50(48h): >100 mg/l nominal concentration.
NOEC (48h): 100 mg/l nominal concentration
Additional information
Algae:
The acute toxicity of Fructose-1,6-Diphosphate, raw: Glucose anaerobically fermented by Saccharomyces cerevisiae, concentrated, phosphorylated (EC no. 944-754-7) to Desmodesmus subspicatus was determined in a 72 hours static test according to OECD guideline 201. The median effect concentration with respect to growth rate (ErC50/0–3 days) of Fructose-1,6-Diphosphate, raw: Glucose anaerobically fermented by Saccharomyces cerevisiae, concentrated, phosphorylated to Desmodesmus subspicatus was estimated to be >119 mg/l measured concentration. The no observed effect concentration (NOErC) with respect to growth rate was determined to be 119 mg/l measured concentration. The results of the test can be considered reliable without restriction.
Daphnia:
The acute toxicity of Fructose-1,6-Diphosphate, raw: Glucose anaerobically fermented by Saccharomyces cerevisiae, concentrated, phosphorylated (EC no. 944-754-7) to Daphnia magna was determined in a 48 hours static test according to OECD guideline 202. The median effect concentrations (EC50) of Fructose-1,6-Diphosphate, raw: Glucose anaerobically fermented by Saccharomyces cerevisiae, concentrated, phosphorylated on Daphnia magna after 24 h as well as after 48 h of exposure were estimated to be >100 mg/l nominal concentration. The NOEC values after 24 h and after 48 h of exposure were both 100 mg/l nominal concentration. The results of the test can be considered reliable without restriction.
Conclusion on classification:
The environmental classification of Fructose-1,6-Diphosphate, raw: Glucose anaerobically fermented by Saccharomyces cerevisiae, concentrated, phosphorylated (EC no. 944-754-7) is currently not harmonised according to the CLP Regulation (EC) 1272/2008. Based on available acute aquatic toxicity data, the lowest valid effect concentration for freshwater aquatic organisms is >100 mg/L (EC50 for aquatic invertebrates). Based on the available acute data, the substance should not be classified for acute toxicity following Annex I, table 4.1.0a of the CLP regulation (there are no acute values <=1 mg/L).
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