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EC number: 276-380-9 | CAS number: 72140-65-9
The dermal irritation potential of MTDID 15670 (unknown form, lot unknown) was evaluated in rabbits. The study design was based on the recommendations in US CFR Title 16, Section 1500.41. Six hair clipped rabbits received test material on one abraded and one intact test site. The test material was held in place with 1 inch x 1 inch gauze, adhesive tape, and an impervious material such as rubberized cloth was wrapped around the torso of the rabbit. After 24 hours of exposure the patches were removed and the sites were scored for erythema and edema (0-4 scales). Observations are recorded at 24 and 72 hours after the exposure period and the scores of all sites are averaged together to produce the primary dermal irritation index (PDII) . Animals were not observed beyond 72 hours after exposure. Erythema (scores: 2-3) and edema (scores: 1-3) were observed at all treated sites at both observation times. Blanching of the skin was observed in intact sites (4 animals) and abraded sites (5 animals) at 24 hours post-exposure. Blanching and cracked skin was observed in 3 animals at 72 hours post-exposure. The PDII was 5.0. Based on the results of this study, MTDID 15670 is a moderate skin irritant.
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