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Stability in organic solvents and identity of relevant degradation products

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Reference
Endpoint:
stability in organic solvents and identity of relevant degradation products
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2016-10-21
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Reference:
Composition 0
Qualifier:
no guideline followed
Principles of method if other than guideline:
The octanol stability of test substance was determined by measuring the concentration of test substance in n-octanol after a period of time and at equilibrium conditions and at ambient temperature.
GLP compliance:
no
Test material information:
Composition 1
Test substance stable:
yes
Remarks:
MTDID 15670 cation was stable in n-octanol for 7 days. MTDID 15670 anion concentration slightly decreased within 7 days, but it was considered relatively stable in n-octanol.
Transformation products:
not measured

MTDID 15670 cation and anion stability in octanol were indicated by the peak ratio of the cation/internal standard or anion/internal standard over the period of seven days (Fig 1). Final concentrations of diluted MTDID 15670 sulfonium cation and PhI-Urea (IS) were 77.5 ng/mL and 98.0 ng/mL, respectively. The RSD% of MTDID 15670 cation concentration (4 time points) was 3.6% (data not shown). Final concentrations of diluted MTDID 15670 tetrafluoroborate anion and PFBS (IS) were 22.5 ng/mL and 98.0 ng/mL, respectively. The RSD% of MTDID 15670 anion concentration (4 time points) was 16% (data not shown).

 

MTDID 15670 cation was stable in n-octanol for 7 days. MTDID 15670 anion concentration decreased slightly within 7 days, but it was consiered relatively stable in n-octanol.

Conclusions:
MTDID 15670 cation was stable in n-octanol for 7 days. MTDID 15670 anion concentration slightly decreased within 7 days, but it was considered relatively stable in n-octanol.
Executive summary:

Stability of MTDID 15670 in n-octanol was studied over a period of seven days. MTDID 15670 contains a sulfonium cation component and a tetrafluoroborate anion component. The cation and anion components were analyzed separately, each at approximately day 0 (0 hour), day 3 (72 hours), day 4 (96 hour) and day 7(168 hour). MTDID 15670 cation and anion stability in octanol were indicated by the peak ratio of the cation/internal standard or anion/internal standard, respectively, over the period of seven days. MTDID 15670 cation was stable in n-octanol for 7 days. MTDID 15670 anion concentration decreased slightly within 7 days, but it was considered relatively stable in n-octanol.

This is a non-GLP preliminary study followed general accepted scientific principles. It is considered reliable with restriction.

Description of key information

MTDID 15670 cation was stable in n-octanol for 7 days. MTDID 15670 anion concentration slightly decr

eased within 7 days, but it was considered relatively stable in n-octanol.

Additional information

Stability of MTDID 15670 in n-octanol was studied over a period of seven days, by analyzing the cation and anion components separately, each at approximately day 0 (0 hour), day 3 (72 hours), day 4 (96 hour) and day 7 (168 hour). MTDID 15670 cation and anion stabilities in n-octanol were indicated by the peak ratio of the cation/internal standard or anion/internal standard, respectively, over the period of seven days. MTDID 15670 cation was stable in n-octanol for 7 days. MTDID 15670 anion concentration decreased slightly within 7 days, but it was considered relatively stable in n-octanol.

This is a non-GLP preliminary study followed general accepted scientific principles. It is considered reliable with restriction.