Registration Dossier
Registration Dossier
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EC number: 279-013-0 | CAS number: 78948-87-5
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- < 0.3
- Temp.:
- 23 °C
- pH:
- 7
- Conclusions:
- The results of the calculation method and the HPLC method are in agreement. Since the HPLC method is a more accurate method than the calculation method, the result of the HPLC method is reported as the partition coefficient (n-octanol/water), Pow of the test substance.
The Pow vaue for Lonzabac MP is < 2 (log Pow < 0.3) at 23°C.
Reference
ln the chromatograms of the 20.2 mg/l Lonzabac MP, L224643, test solution which were recorded for 5 minutes, one large test substance peak was observed at a retention time of 0.730 minutes. Under the same chromatographic conditions, the retention time of ethylmethylketone (log Pow, = 0.3) was 1.70 minutes. lt has to be noted that in the chromatogram of ethylmethylketone (see Figure 3) an additional peak at 1.085 min is present. Based on experience, this peak can be attributed to an impurity, which is always present in ethylmethylketone at varying concentrations.
Hence, it was concluded that the log Pow of Lonzabac MP, L224643, is < 0.3 (Pow < 2).
Description of key information
The results of the calculation method and the HPLC method are in agreement. Since the HPLC method is a more accurate method than the calculation method, the result of the HPLC method is reported as the partition coefficient (n-octanol/water), Pow of the test substance.
The Pow vaue for Lonzabac MP is < 2 (log Pow < 0.3) at 23°C.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -1.47
- at the temperature of:
- 20 °C
Additional information
The result of <0.3 was determined by HPLC method. The value for risk assessment was derived from shake flask method.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
