Registration Dossier
Registration Dossier
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EC number: 947-953-7 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
Justification for classification or non-classification
Skin irritation / corrosion
In a recent in vitro skin irritation study the test item showed a mean relative tissue viability of < 5.7%. The test item is considered irritant to the skin if the mean relative tissue viability of three individual tissues is reduced ≤ 50% of the negative control. Since the tissue viability was below the treshold of 50%, the substance is considered skin irritant.
Further testing to assess the skin corrosion potential was performed. After 3 minutes treatment the relative absorbance was decreased to 85.1%, which is well above the treshold for corrosivity (50%). After 1h treatment, relative absorbance value was reduced to 41.8, which is also well above the treshold value of 15%. Hence, the substance is considered as non-corrosive.
The combination of both studies results to the final classification of the test item as skin irritant category 2 according to CLP EC No 1272/2008.
Eye irritation
A EpiOcularTM Eye Irritation Test (OECD 492) test has been performed to assess the eye irritation potential of the substance. Test results indicate that test item is either eye irritant or inducing serious eye damage. The substance is therefore conservatively classified as eye irritant category 1 according to CLP EC No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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