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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study has been assessed for the use in a category approach. According to the methodology and to the extent of available details, the study has been judged as reliable with restrictions.

Data source

Reference
Reference Type:
publication
Title:
The toxicity of sodium tartrate with special reference to diet and tolerance.
Author:
W. Salant
Year:
1913
Bibliographic source:
U. S. Department of Agriculture, Bureau of Animal Industry, Washington, D. C.

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Subcutaneous exposition of in vivo animals to the substance to evaluate its acute toxicity.
GLP compliance:
not specified
Test type:
other: no data

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
No further details on test material are available
Specific details on test material used for the study:
no data

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
no data

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
no data
Duration of exposure:
no data
Doses:
400 mg/kg
800 mg/kg
1000 mg/kg
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
no data
Statistics:
no data

Results and discussion

Preliminary study:
no data
Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
other: lethal dose
Effect level:
ca. 400 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 6/7 animals died in 6-7 days
Sex:
not specified
Dose descriptor:
other: lethal dose
Effect level:
ca. 1 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: no effects
Sex:
not specified
Dose descriptor:
other: lethal dose
Effect level:
>= 1 200 - <= 1 500 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Toxic
Sex:
not specified
Dose descriptor:
other: lethal dose
Effect level:
ca. 800 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 6/9 rabbits survived

Any other information on results incl. tables

Animals which were fed oats or oats and cabbage succumbed to a dose of 0.4 gm. of the salt per kilo when given by subcutaneous injection, Suppression of urine was usually observed on the first day and death occurred in six to seven days. In starvation, slightly smaller doses were fatal to some rabbits. The resistance was increased considerably when the diet was changed to carrots, Such animals stood 1.0 gm. per kilo by subcutaneous injection, while 1.2-1.5 gm. per kilo were toxic. A moderate degree of tolerance for tartrates was induced in animals which were fed oats and cabbage. By gradually increasing the dose, a large proportion (6 out of 9) of rabbits survived 0.8 gm. per kilo which is twice the fatal dose. Rabbits which were receiving carrots did not acquire tolerance for tartrates.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Sodium tartrate showed different tolerance which depended on diet following subcutaneous administration.
Executive summary:

Sodium tartrate showed different tolerance which depended on diet following subcutaneous administration.