Registration Dossier
Registration Dossier
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EC number: 213-067-8 | CAS number: 921-53-9
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1910
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study has been assessed for the use in a category approach. According to the methodology and to the extent of available details, the study has been judged as reliable with restrictions.
Data source
Reference
- Reference Type:
- publication
- Title:
- Alterazioni anatomo-patologiche nell' avvelenamento per acido tartarico e citrico
- Author:
- Connio G.
- Year:
- 1 910
- Bibliographic source:
- Pathologica 1910 (3): 428-429.
Materials and methods
- Study type:
- poisoning incident
- Endpoint addressed:
- acute toxicity: oral
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
Test material
- Reference substance name:
- (+)-tartaric acid
- EC Number:
- 201-766-0
- EC Name:
- (+)-tartaric acid
- Cas Number:
- 87-69-4
- Molecular formula:
- C4H6O6
- IUPAC Name:
- (2R,3R)-2,3-dihydroxybutanedioic acid
- Test material form:
- not specified
Constituent 1
Method
- Type of population:
- general
- Subjects:
- 2 adults
- Ethical approval:
- not specified
- Route of exposure:
- oral
- Reason of exposure:
- intentional
- Exposure assessment:
- estimated
- Details on exposure:
- Doses: from 50 up to 60 g of tartaric acid for each subject.
Results and discussion
- Clinical signs:
- At the begining - after injection - intense burning sensation for throat and stomach, vomiting, diarrhea, serious demages on the kidneys
- Results of examinations:
- Necroscopy was performed but in one case not reliable data were available. In the other case, an acute inflammation in the kidneys were observed; this observation was also confirmed after microscopic evaluation.
- Effectivity of medical treatment:
- no data
- Outcome of incidence:
- Death occured for all the two subjects.
Applicant's summary and conclusion
- Conclusions:
- After voluntary injection of 50-60 g of tartaric acid in two subjects, death occured for all the two people.
In one case, an acute inflammation in the kidneys were observed; this observation was also confirmed after microscopic evaluation.
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