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Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1910
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study has been assessed for the use in a category approach. According to the methodology and to the extent of available details, the study has been judged as reliable with restrictions.

Data source

Reference
Reference Type:
publication
Title:
Alterazioni anatomo-patologiche nell' avvelenamento per acido tartarico e citrico
Author:
Connio G.
Year:
1910
Bibliographic source:
Pathologica 1910 (3): 428-429.

Materials and methods

Study type:
poisoning incident
Endpoint addressed:
acute toxicity: oral
Test guideline
Qualifier:
no guideline followed
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
not specified

Method

Type of population:
general
Subjects:
2 adults
Ethical approval:
not specified
Route of exposure:
oral
Reason of exposure:
intentional
Exposure assessment:
estimated
Details on exposure:
Doses: from 50 up to 60 g of tartaric acid for each subject.

Results and discussion

Clinical signs:
At the begining - after injection - intense burning sensation for throat and stomach, vomiting, diarrhea, serious demages on the kidneys
Results of examinations:
Necroscopy was performed but in one case not reliable data were available. In the other case, an acute inflammation in the kidneys were observed; this observation was also confirmed after microscopic evaluation.
Effectivity of medical treatment:
no data
Outcome of incidence:
Death occured for all the two subjects.

Applicant's summary and conclusion

Conclusions:
After voluntary injection of 50-60 g of tartaric acid in two subjects, death occured for all the two people.
In one case, an acute inflammation in the kidneys were observed; this observation was also confirmed after microscopic evaluation.