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Toxicological information

Health surveillance data

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Administrative data

Endpoint:
health surveillance data
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study has been assessed for the use in a category approach. According to the methodology and to the extent of available details, the study has been judged as reliable with restrictions.

Data source

Reference
Reference Type:
publication
Title:
Indagine su un gruppo di soggetti con esposizione professionale ad acido tartarico
Author:
Moscato et al.
Year:
1983
Bibliographic source:
ltal. Med. Lav. 1983; 5: 193-198.

Materials and methods

Study type:
medical monitoring
Endpoint addressed:
skin irritation / corrosion
eye irritation
respiratory irritation
repeated dose toxicity: oral
other: spirometry... (see attached file)
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
no data
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
not specified
Details on test material:
No details on test material identity are available.

Method

Type of population:
occupational
Ethical approval:
not specified
Details on study design:
Evaluation of human workers occupationally-exposed to tartaric acid.
The study reports the results of un investigation carried out in a factory producing tartaric acid in order to evaluate the effects of occupational exposure to tartaric acid. A group of 74 subjects exposed to the acid and a group of 30 subjects not exposed, as a means of control, were submitted to unamnestic questionnaire.

Results and discussion

Results:
The most frequent symptoms in the exposed group is represented by:
- Nasal obstruction
- itch and sneeze
- Hypo-anosmia
- Nosebleed
- Sore throat
- Dysphonia
- Skin irritation
- Ulceration
The investigations carried out have shown in the group of subjects exposed to tartaric acid the presence of lesions cutaneous and nasopharyngeal, that develop with mode that appear with different and significantly greater frequency compared to the control group. The skin lesions are localized, for the most part the hands and depend from direct contact with the powder.

Any other information on results incl. tables

Responses to the questionnaires

Examined group

nasopharyngeal symptoms

skin

disorder

eye

disorder

gastrointestinal disorder

tooth

disorder

exposed

20*

(45.45%)

34*

(77.3%)

23

(52.3%)

21

(47.7%)

27

(61.4%)

control group

not exposed

2

(6.7%)

6

 (20%)

8

(26.7%)

13

(43.3%)

11

(36.7%)

* p <0.001 data statistically significant.

Applicant's summary and conclusion

Conclusions:
Data show a higher prevalence of oropharyngeal and cutaneous lesions in the exposed subjects, while no difference between the two groups was found for dental, bronchial and gastric lesions.
Executive summary:

Data show a higher prevalence of oropharyngeal and cutaneous lesions in the exposed subjects, while no difference between the two groups was found for dental, bronchial and gastric lesions.