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EC number: 211-779-3 | CAS number: 695-12-5
In a dermal sensitization study conducted according to OECD 442D with Vinylcyclohexane (99.8% purity) in DMSO, the sensitization potential of the test item was assessed on the basis of the activation of keratinocytes using the genetically modified keratinocyte cell line 'LuSens'. Cells were incubated with the test item for 48 h at different concentrations (34 µM, 40 µM, 48 µM, 58 µM, 70 µM, 84 µM, 100 µM, 121 µM, 145 µM, 174 µM, 208 µM, 250 µM) and later checked for luciferase activity.
Sensitization was scored by measuring the luciferase activity induction and relative cell viability. For both experiment I and II, the fold induction was less than a 1.5 and the cell viability was greater than 70%. Therefore, in this study, the test item is not considered to be a skin sensitizer under UN GHS guidelines.
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