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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
July - September 1965
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
The toxicology of vinylcyclohexane
Author:
Savchenkov M.F.
Year:
1965
Bibliographic source:
Gigiena i Sanitariya 30 Vol. 7, 32-37

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The experiments were performed on white mice and albino rats, some being healthy adult and young animals and some weakened by avitaminosis and insufficient feeding. The animals were kept in chambers that were exposed to vapours of the substance whose concentration was predetermined by a method developed by a worker at the Dushutin Institute.
GLP compliance:
not specified
Test type:
traditional method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
other: white mice and albino rats
Strain:
not specified
Sex:
male/female
Details on test animals and environmental conditions:
not specified

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
air
Details on study design:
The experiments were performed on white mice and albino rats, some being healthy adult and young animals and some weakened by avitaminosis and insufficient feeding. The concentration of the substance in the chamber was determined by amethod developed by a worker at the Dushutin Institute which is based on the color resulting from the reaction of VCH with concentrated sulfuric acid.

Results and discussion

Effect levelsopen allclose all
Sex:
male/female
Dose descriptor:
LC50
Effect level:
13.7 mg/L air
Based on:
test mat.
Remarks on result:
other: healthy mice
Sex:
male/female
Dose descriptor:
LC50
Effect level:
20.5 mg/L air
Based on:
test mat.
Remarks on result:
other: healthy rats
Mortality:
Mortality occurred and some animals died during the spasmodic attacks.
Clinical signs:
other: - The animals exposed to high concentrations of these vapours immediately showed signs of excitation, increased breathing and staggering gait. They fell, rose again, were suddenly seized by tonic spasms of extreme intensity, fell on their sides and develo
Body weight:
Not specified
Gross pathology:
Not specified
Other findings:
- The substance possessed a narrow toxic range and was more highly toxic for the young and weakened animals
- There were no significant differences in the sensitivity of males and females
- the absolute lethal concentration was 15 mg/L and partially lethal concentration was 12.5 mg/L in healthy mice
- In case of weakened mice the LC50 was 10.6 mg/L
- The LC50 for young rats (60 - 80 g bw) was 17 mg/L
- Animals that had survived the acute poisoning (exposed to LD50) were again exposed to the test item vapour concentration of 15 mg/L for 2 hours the following day. Not a single experimental animal died and none even fell on its side

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
Based on the results the LC50 for rats was estabilshed to be 20.5 mg/mL and 13.7 mg/L for mice.
Executive summary:

Based on the results, the LC50 for rats was estabilshed to be 20.5 mg/mL and 13.7 mg/L for mice.