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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
July - September 1965
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
The toxicology of vinylcyclohexane
Author:
Savchenkov M.F.
Year:
1965
Bibliographic source:
Gigiena i Sanitariya 30 Vol. 7, 32-37

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
The test item was fed to mice and rats in doses of up to 2000 mg/kg bw and 4000 mg/kg bw pure substance.
GLP compliance:
not specified
Test type:
other: Acute experiment
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
other: white mice and albino rats
Strain:
not specified
Sex:
male/female
Details on test animals and environmental conditions:
Not specified

Administration / exposure

Route of administration:
oral: feed
Vehicle:
other: refined sunflower oil
Details on oral exposure:
VEHICLE: Refined Sunflower oil


DOSAGE PREPARATION (if unusual): The test item was fed to mice and rats in doses of up to 2 g / kg and another dose of 4 g / kg, pure substance mixed with sunflower oil. The dose of 4 g / kg was administered with and without sunflower oil.
Doses:
2000 mg/kg bw and 4000 mg/kg bw
Control animals:
not specified
Details on study design:
- Necropsy of survivors performed: yes

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Mortality:
A dose of 4000 mg/kg bw killed some of the animals when administered in a mixture with refined flower oil and killed all of then when administered alone. At 2000 mg/kg bw pure substance mixed with sunflower oil had a slight toxic effect, causing the animals to loose weight.
Body weight:
At 2000 mg/kg bw the animals lost weight.
Gross pathology:
Organs of the dead animals showed degenerative changes in the liver and kidneys and signs of stimulation in the spleen.
Other findings:
- Organ weights: there was a considerable increase in the weight coefficients of the liver and spleen (p >0.01).

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Based on the results of this study, the oral LD50 can be considered to be greater than 2000 mg/kg bw in rat and mouse.
Executive summary:

In an acute oral toxicity study, a dose of 4000 mg/kg bw of the test item killed some of the animals when administered in a mixture with refined flower oil and killed all of them when administered alone. At 2000 mg/kg bw the pure substance mixed with sunflower oil had only a slight toxic effect, causing the animals to loose weight. Moreover, organs of the dead animals showed degenerative changes in the liver and kidneys and signs of stimulation in the spleen and a considerable increase in the weight coefficients of the liver and spleen (p> 0.01) was recorded. Based on the results, the oral LD50 in rats and mice can be considered to be greater than 2000 mg/kg bw.