Vinylcyclohexane

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

July - September 1965

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

documentation insufficient for assessment

Data source

Reference

Reference Type:

publication

Title:

The toxicology of vinylcyclohexane

Author:

Savchenkov M.F.

Year:

1965

Bibliographic source:

Gigiena i Sanitariya 30 Vol. 7, 32-37

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

The test item was fed to mice and rats in doses of up to 2000 mg/kg bw and 4000 mg/kg bw pure substance.

GLP compliance:

not specified

Test type:

other: Acute experiment

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Vinylcyclohexane

EC Number:

211-779-3

EC Name:

Vinylcyclohexane

Cas Number:

695-12-5

Molecular formula:

C8H14

IUPAC Name:

ethenylcyclohexane

Test animals

Species:

other: white mice and albino rats

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

Not specified

Administration / exposure

Route of administration:

oral: feed

Vehicle:

other: refined sunflower oil

Details on oral exposure:

VEHICLE: Refined Sunflower oil


DOSAGE PREPARATION (if unusual): The test item was fed to mice and rats in doses of up to 2 g / kg and another dose of 4 g / kg, pure substance mixed with sunflower oil. The dose of 4 g / kg was administered with and without sunflower oil.

Doses:

2000 mg/kg bw and 4000 mg/kg bw

Control animals:

not specified

Details on study design:

- Necropsy of survivors performed: yes

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Mortality:

A dose of 4000 mg/kg bw killed some of the animals when administered in a mixture with refined flower oil and killed all of then when administered alone. At 2000 mg/kg bw pure substance mixed with sunflower oil had a slight toxic effect, causing the animals to loose weight.

Gross pathology:

Organs of the dead animals showed degenerative changes in the liver and kidneys and signs of stimulation in the spleen.

Other findings:

- Organ weights: there was a considerable increase in the weight coefficients of the liver and spleen (p >0.01).

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

Based on the results of this study, the oral LD50 can be considered to be greater than 2000 mg/kg bw in rat and mouse.

Executive summary:

In an acute oral toxicity study, a dose of 4000 mg/kg bw of the test item killed some of the animals when administered in a mixture with refined flower oil and killed all of them when administered alone. At 2000 mg/kg bw the pure substance mixed with sunflower oil had only a slight toxic effect, causing the animals to loose weight. Moreover, organs of the dead animals showed degenerative changes in the liver and kidneys and signs of stimulation in the spleen and a considerable increase in the weight coefficients of the liver and spleen (p> 0.01) was recorded. Based on the results, the oral LD50 in rats and mice can be considered to be greater than 2000 mg/kg bw.