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EC number: 205-531-3 | CAS number: 142-28-9
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1984
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- PubChem CID 8881 1,3-Dichloropropane
- Author:
- Kim S, Thiessen PA, Bolton EE, Chen J, Fu G, Gindulyte A, Han L, He J, He S, Shoemaker BA, Wang J, Yu B, Zhang J, Bryant SH. PubChem Substance and Compound databases. Nucleic Acids Res. 2016 Jan 4; 44(D1):D1202-13. Epub 2015 Sep 22 [PubMed PMID: 26400175] doi: 10.1093/nar/gkv951.
- Year:
- 2 018
- Bibliographic source:
- https://pubchem.ncbi.nlm.nih.gov/compound/1_3-dichloropropan
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 984
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Version / remarks:
- guideline not reported but results show application of OECD 471 or similar methods
- Deviations:
- not applicable
- Principles of method if other than guideline:
- no data available
- GLP compliance:
- not specified
- Remarks:
- reliable data from handbook or collection of data but without specification of method. GLP not specified but quality similar to GLP assumed.
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 1,3-dichloropropane
- EC Number:
- 205-531-3
- EC Name:
- 1,3-dichloropropane
- Cas Number:
- 142-28-9
- Molecular formula:
- C3H6Cl2
- IUPAC Name:
- 1,3-dichloropropane
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Test substance synthesized according to Hooz, J., and S.S.H. Gilani (1968) A rapid mild procedure for the preparation of alkyl chlorides and bromides, Can. J. Chem., 46, 86.
Method
- Target gene:
- hisG46 in Salmonella LT-2 derivatives: TA1530 (hisG46, Agal, AuvrB), TA1535 (hisG46, rfa, AuvrB) and T100 (hisG46, rfa, AuvrB, pKM101) as described by Ames, B.N., J. McCann and E. Yamasaki (1975) Methods for detecting carcinogens and mutagens with the Salmonella mammalian microsome mutagenicity test, Mutation Res., 31, 347-364. supplied by Dr. B. Ames, Berkeley (U.S.A.)
Species / strainopen allclose all
- Species / strain / cell type:
- S. typhimurium TA 100
- Additional strain / cell type characteristics:
- other: hisG46 base pair substitution histidine deficiency uvrB deletion UV sensitivity, biotin deficiency rfa deletion lipopolysaccharide side chain deficiency
- Species / strain / cell type:
- S. typhimurium, other: TA1530
- Additional strain / cell type characteristics:
- other: hisG46, Agal, AuvrB
- Species / strain / cell type:
- S. typhimurium TA 1535
- Additional strain / cell type characteristics:
- other: hisG46 base pair substitution histidine deficiency uvrB deletion UV sensitivity, biotin deficiency rfa deletion lipopolysaccharide side chain deficiency
- Metabolic activation:
- without
Results and discussion
Test resultsopen allclose all
- Key result
- Species / strain:
- S. typhimurium TA 100
- Metabolic activation:
- without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Key result
- Species / strain:
- S. typhimurium, other: TA1530
- Metabolic activation:
- without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Key result
- Species / strain:
- S. typhimurium TA 1535
- Metabolic activation:
- without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
Applicant's summary and conclusion
- Conclusions:
- no in vitro gene mutation potentail observed in 3 strains of Salmonella typhimurium (TA100, TA1530, TA1535)
- Executive summary:
in vitro tests with 3 strains of Salmonella typhimurium (TA100, TA1530, TA1535), according to the method of Ames, B.N., J. McCann and E. Yamasaki ((1975) Methods for detecting carcinogens and mutagens with the Salmonella mammalian microsome mutagenicity test, Mutation Res., 31, 347-364), no genotoxic potential of 1,3-Dichloropropane was detectable.
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