Registration Dossier
Registration Dossier
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EC number: 205-531-3 | CAS number: 142-28-9
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1989
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 989
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPPTS 835.2130 (Hydrolysis as a Function of pH and Temperature)
- Deviations:
- not specified
- Remarks:
- not refered to guidelines
- Principles of method if other than guideline:
- Study is mentioned in PubChem which supplies reliable data (from handbook or collection of data) but without specification of method
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,3-dichloropropane
- EC Number:
- 205-531-3
- EC Name:
- 1,3-dichloropropane
- Cas Number:
- 142-28-9
- Molecular formula:
- C3H6Cl2
- IUPAC Name:
- 1,3-dichloropropane
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- The supplier of the test item is not specified, but it is stated that the chlorinated compounds were obtained from Aldrich, Eastman, or Pfaltz and Bauer and were of the highest purity available.
- Radiolabelling:
- no
Study design
- Analytical monitoring:
- yes
- Details on test conditions:
- 101 - 190 °C in neutral range, 85-132 °C in basic range
pH 3 - 14
solution was 2700 mg/L
Results and discussion
- Transformation products:
- not specified
Dissipation DT50 of parent compound
- Key result
- pH:
- 7
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0 min-1
- DT50:
- ca. 2.2 yr
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: neutral hydrolysis
- Other kinetic parameters:
- Arrhenlus plot for alkallne hydrolysis reactlons exhibit second order k values (L mol-' mln-').
Arrhenlus plot for neutral hydrolysis reactlons exhibit first order k values.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Hydrolysis is very slow in (pure) water
- Executive summary:
Cited from PubChem: "The hydrolysis rate constant of 1,3-dichloropropane was measured in dilute aqueous solutions within the temperature ranges of 101 to 190 deg C (neutral range) and 85 to 132 deg C (basic range), and at pH values of 3 to 13. The environmental half life of 1,3-dichloropropane (at 25 deg C, pH 7) is 2.2 yr."
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