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EC number: 217-565-6 | CAS number: 1888-91-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1998-09-08 to 1998-09-29
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline conform study report, GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Remarks:
- Statement
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- N-acetylhexanelactam
- EC Number:
- 217-565-6
- EC Name:
- N-acetylhexanelactam
- Cas Number:
- 1888-91-1
- Molecular formula:
- C8H13NO2
- IUPAC Name:
- 1-acetylazepan-2-one
- Reference substance name:
- 1888-91-0
- IUPAC Name:
- 1888-91-0
- Test material form:
- other: liquid, clear yellowish
- Details on test material:
- - Name of test material: Acetylcaprolactam
- Physical state: liquid
- Analytical purity: 100%
- Lot/batch No.: Op.2
- Expiration date of the lot/batch: December 1999
- Stability under test conditions: guaranteed for 4 hours
- Storage condition of test material: darkness at room temperature in fume cupboard
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: sesame oil
- Doses:
- 1600, 2000 and 2500 mg/kg bw
- No. of animals per sex per dose:
- at 1600 mg/kg bw: 5 males/ 5 females
at 2000 mg/kg bw: 5 females
at 2500 mg/kg bw: 5 females - Control animals:
- no
- Statistics:
- The LD50 and the equation of the probitline were established in female animals on the basis of the letahity rates by probit analysis.
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 836 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Under the conditions described the following lethality rates were observed:
males:
1600 mg/kg bw: absolute 0/5 males; relative: 0%
females:
1600 mg/kg bw: absolute 2/5 females; relative: 40%
2000 mg/kg bw: absolute 2/5 females; relative: 40%
2500 mg/kg bw: absolute 5/5 females; relative: 100% - Clinical signs:
- other: Clinical sighn observed were: hypoactivity, stupor, sunken flanks, bristled coat, stilted gait, uncoordinated gait, ataxia, irregular respiration, narrowed palpebral fissures, prone position, absent paw reflex to pinching, absent righting reflex and narco
- Gross pathology:
- Macroscopic findings of animals found dead
Liver: light discoloration;
Stomach: detachment of the mucous membrane
Small intestine: diffuse reddening
Lung: discoloured red.
Animals sacrified at the scheduled end of observation period showed no macroscopically visible changes.
Any other information on results incl. tables
Under the conditions described the following lethality rates were observed:
males:
1600 mg/kg bw: absolute 0/5 males; relative: 0%
females:
1600 mg/kg bw: absolute 2/5 females; relative: 40%
2000 mg/kg bw: absolute 2/5 females; relative: 40%
2500 mg/kg bw: absolute 5/5 females; relative: 100%
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral median lethal dose (LD50) in female Sprague Dawley rats was found to be 1836 mg/kg bw.
- Executive summary:
In an OECD 401 study the acute oral median lethal dose (LD50) of the test substance to the Sprague Dawley strain rat was found to be 1836 mg/kg bw. Doses of 1600, 2000 or 2500 mg/kg bw in sesame oil were applied once to the rats by gavage. Whereas 1600 mg/kg bw was applied to 5 male and 5 female rats, the remaining two doses were applied to 5 female rats each. Mortality occured in 5/5 female rats at 2500 mg/kg bw, in 2/5 females at 2000 mg/kg bw and in 2/5 females at 1600 mg/kg bw. No death occurred in male rats at 1600 mg/kg bw.
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