Registration Dossier

Administrative data

Description of key information

LD50 oral rat > 2000 mg/kg bw (OECD 423)

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
discriminating dose
2 000 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

The test item is a solution of the registered substance in ethyl acetate (solid content about 40 %); the solid content was considered for the preparation of the tested dose.

The acute oral LD50 in rats is determined with > 2000 mg/kg bw based on the results of a limit dose study performed according to OECD TG 423. The test dose of 2000 mg/kg was well tolerated, without effects on body weight development and gross pathological findings.

Although no acute dermal toxicity study is available the dermal systemic toxicity potential can be predicted to be low based on the fact that the substance exerts no acute oral toxicity and no systemic effects have been observed in an in vivo study with dermal exposure (skin sensitization).

Justification for classification or non-classification

No classification is warranted for acute oral and dermal toxicity.

No data are available for acute inhalation toxicity.