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Boiling point

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Reference
Endpoint:
boiling point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
15 January 2018 to 7 February 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Reference:
Composition 0
Qualifier:
according to
Guideline:
OECD Guideline 103 (Boiling Point)
Version / remarks:
27 July 1995
Deviations:
no
GLP compliance:
yes (incl. certificate)
Other quality assurance:
ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
Type of method:
differential scanning calorimetry
Test material information:
Composition 1
Specific details on test material used for the study:
Test Item

Identification: Dermol GTR
Appearance: Clear light amber liquid
Purity/Composition: >90%
Test item storage: At room temperature

Additional information
Test Facility test item number: 209077/A
Purity/Composition correction factor: No correction factor required
Test item handling: No specific handling conditions required
Molecular structure: Not indicated
Molecular formula: C63H110O12
Molecular weight: 1059

Test Item Characterization
The Sponsor provided to the Test Facility documentation of the identity, purity, composition, and stability for the test item(s). A Certificate of Analysis or equivalent document was provided to the Test Facility and is presented in Appendix 2.
Key result
Decomposition:
yes
Remarks on result:
not determinable

No boiling point, reaction/decomposition.

Preliminary test

The TGA curve of the test item is shown inFigure 1. Starting at 350°C, the weight of the sample decreased significantly. At 410°C, the sample weight had decreased by 25%.

After the experiment, a yellow molten residue remained in the sample container (original colour: colourless) and a yellow residue was observed on the lid of the sample container. The change of the colour indicated reaction and/or decomposition of the test item.

Main study

The DSC curve obtained with Experiment 1 is shown inFigure 2. During cooling a glass transition was observed between -60°C and -80°C. During heating aglass transition was observed between -90°C and -50°C followed by an endothermic effect starting at 250°C. The inflection point temperature of the glass transition was -75.782°C. The endothermic effect was probably obtained due to reaction and/or decomposition of the test item.

After the experiment, a light yellow molten residue remained in the sample container (original colour: colourless). The change of the colour indicated reaction and/or decomposition of the test item. 

Experiment 2 was performed as a duplicate of Experiment 1. Figure 3 shows the DSC curve obtained. Similar results as in Experiment 1 were obtained. The inflection point of the glass transition was -76.001°C. After the experiment, a colourless residue remained in the sample container. 

The glass transition was determined as the mean inflection point of Experiment 1 (-75.782°C) and Experiment 2 (-76.001°C).

Conclusions:
No boiling point, reaction/decomposition.
The melting and boiling temperature of Dermol GTR were determined by DSC.
No melting point was determined. A glass transition of the test item was observed at -75.9°C (197.3K).
Reaction and/or decomposition of the test item was observed during DSC experiment at temperatures of > 250°C (> 523K). Boiling of the test item was not observed below the temperature at which reaction and/or decomposition started. Based on this, the test item has no boiling temperature.
Executive summary:

In this guideline (OECD 103) study, conducted with GLP certification, EC 202-935-1n was determined as having no boiling point due to decomposition during the DSC experiment.

Description of key information

Study performed to recognised study guidelines with GLP certification.

Key value for chemical safety assessment

Additional information

In this guideline (OECD 103) study, conducted with GLP certification, EC 202-935-1 was determined as having no boiling point due to decomposition during the DSC experiment.