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Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Additional information

There are no terrestrial data available for sodium p-chloro-m-cresolate (CAS 15733-22-9). Therefore, a read-across approach was conducted to compile relevant data from a structurally and chemically related source substance in order to fulfill the standard information requirements laid down in Annex VIII of REACH Regulation (EC) No 1907/2006. The read-across was conducted in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5.

This read-across is based on the hypothesis that the source substance (p-chloro-m-cresol, CAS 59-50-7) and the target substance (sodium p-chloro-m-cresolate) have similar respectively the same toxicological and eco-toxicological properties. The target substance is transformed by hydrolysis into the source substance and sodium cation. The source substance p-chloro-m-cresol is the common compound in this analogue approach and is solely responsible for the (absence of) effects. Thus, the source substance is considered a suitable representative for the evaluation of the toxicity of the target substance to terrestrial organisms. The read-across approach is justified in detail within the analogue justification in IUCLID section 13.

Acute and chronic tests evaluating the toxicity of p-chloro-m-cresol (CAS 59-50-7) to terrestrial organisms are available. The toxicity of the test item to earthworms was assessed in two studies the respective NOEC based on reproduction was determined to be 10 mg/kg soil dw. The toxicity to terrestrial plants was investigated in one long and one short-term study. The overall lowest NOEC was 100 mg/kg soil dw. The toxicity to soil macroorganisms and microorganisms was investigated in two studies. The EC50 was 555.1 mg/kg soil dw and the NOEC 300 mg/kg soil dw.

Based on the available results from a structurally similar source substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which is the main transformation product of the target substance and is characterized by a similar ecotoxicological profile and comparable structure, it can be concluded that sodium p-chloro-m-cresolate has effects in the same range as the target substance.