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Toxicity to aquatic algae and cyanobacteria

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toxicity to aquatic algae and cyanobacteria
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
Please refer to the analogue justification attached to IUCLID section 13.
Reason / purpose:
read-across source
72 h
Dose descriptor:
Effect conc.:
> 13 000 mg/L
Nominal / measured:
Conc. based on:
test mat.
Basis for effect:
cell number

Description of key information

No toxic effects up to the limit of water solubility for Scenedesmus subspicatus ( ISO 8692); read-across

Key value for chemical safety assessment

Additional information

Experimental studies investigating toxic effects of the target substance Fatty acids, C18-unsaturated, 1,6 Hexanediol Diester on aquatic algae are not available. Thus, in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5 a read across to the structurally related source substance Bis(tridecyl) adipate (CAS 16958-92-2) was conducted to fulfill the data requirements according to Annex VII. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment. This read-across is justified in detail within the analogue justification in IUCLID Section 13.

The toxicity of Bis(tridecyl) adipate (CAS 16958-92-2) to freshwater algae was tested according to ISO guideline 8692 using Scenedesmus subspicatus as test organism. Filtered test item solutions of loading rates between 13 and 13000 mg/L were tested. Based on cell numbers no inhibition was observed in any of the treatments. Based on the observations an EL50(72 h) of > 13000 mg/L based on the nominal test concentrations was determined (EL10 (72 h)> 13000 mg/L). The 72 h-NOELR was determined to be ≥ 13000 mg/L.

Based on the available data for the read across substance and the very low water solubility (<0.57 µg/L at 20°C, pH 6.3) of the target substance acute or chronic toxicity of Fatty acids, C18-unsaturated, 1,6 Hexanediol Diester on algae are not expected.