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Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Reference
Endpoint:
long-term toxicity to aquatic invertebrates
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
Please refer to the analogue justification attached to IUCLID section 13.
Reason / purpose:
read-across source
Duration:
21 d
Dose descriptor:
NOEC
Effect conc.:
>= 56 µg/L
Nominal / measured:
meas. (arithm. mean)
Conc. based on:
test mat.
Basis for effect:
reproduction
Duration:
21 d
Dose descriptor:
EC10
Effect conc.:
> 56 µg/L
Nominal / measured:
meas. (arithm. mean)
Conc. based on:
test mat.
Basis for effect:
reproduction

Description of key information

No long-term effects up to the limit of water solubility for Daphnia magna (OECD 211); read across

Key value for chemical safety assessment

Additional information

Experimental studies investigating chronic toxic effects of the target substance Fatty acids, C18-unsaturated, 1,6 Hexanediol Diester on Daphnia magna are not available. Thus, in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5 a read across to the structurally related source substance Hexanedioic acid, di-C16-18 alkyl esters (CAS 92969-90-9) was conducted to fulfill the data requirements according to Annex VII. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment. This read-across is justified in detail within the analogue justification in IUCLID Section 13.

The toxicity of Hexanedioic acid, di-C16-18 alkyl esters (CAS 92969-90-9) to Daphnia magna was tested under semi-static conditions according to OECD guideline 211 under GLP conditions. D. magna was exposed to nominal concentrations of 1.0, 3.2, 10, 32 and 100 µg/L (0.19, 0.19, 1.1, 12 and 56 µg/L (mean measured concentrations)) for 21 days. Due to the low solubility of the test item dimethylformamide (DMF) was used as a solvent. Due to the decrease of test substance concentration during testing the results were based on average measured concentrations over the 21-day test period. Hexanedioic acid, di-C16-18 alkyl esters did not affect reproduction of Daphnia magna. Thus a NOEC (21 d) ≥ 56 µg/L was determined. Based on the available data for the read across substance and the very low water solubility (<0.57 µg/L at 20°C, pH 6.3) of the target substance a chronic toxicity of Fatty acids, C18-unsaturated, 1,6 Hexanediol Diester is not expected.