Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

The release of ytterbium, zirconium or hafnium from the target substance zirconium oxide, hafnium and ytterbium doped in simulated body fluids indicated that the bio-accessibility is very low for all routes (see section 7.1.1). The hafnium release was below the detection limit, the zirconium release was 0.02 µg/mL and the ytterbium release was 3.24 µg/mL from the target substance within 24 hours in artificial perspiration fluid. Thus, the bioavailability of hafnium, zirconium and/or ytterbium after administration to the skin can expected to be very low. No information was found in the public domain, which would have indicated any skin sensitising properties of hafnium, zirconium and/or ytterbium. Based on the results and in line with the 3R principles, the study is scientifically unjustified.

Key value for chemical safety assessment

Skin sensitisation

Link to relevant study records
Reference
Endpoint:
skin sensitisation: in vitro
Data waiving:
study technically not feasible
Justification for data waiving:
other:
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)

Justification for classification or non-classification

The release of ytterbium, zirconium or hafnium from the target substance zirconium oxide, hafnium and ytterbium doped in simulated body fluids indicated that the bio-accessibility is very low for all routes (see section 7.1.1). The hafnium release was below the detection limit, the zirconium release was 0.02 µg/mL and the ytterbium release was 3.24 µg/mL from the target substance within 24 hours in artificial perspiration fluid. Thus, the bioavailability of hafnium, zirconium and/or ytterbium after administration to the skin can expected to be very low. No information was found in the public domain, which would have indicated any skin sensitising properties of hafnium, zirconium and/or ytterbium. Based on the results and in line with the 3R principles, the study is scientifically unjustified. Based on the low release of test item components to the skin, skin sensitising properties are not expected and therefore no classification is warranted.