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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1973
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973
Report Date:
1973

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Not specified.
GLP compliance:
no
Remarks:
Test carried out prior to GLP
Test type:
fixed dose procedure
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
other: Not specified
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Duration of exposure:
14 days
No. of animals per sex per dose:
6
Control animals:
no
Details on study design:
6 animals dosed

Results and discussion

Preliminary study:
none
Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
< 5 000 mg/kg bw
Based on:
test mat.
Mortality:
After 14 days:
- 4 animals found dead at the dose level tested.
Moderate erythema, morbidity (lethargy, malaise), prostration, coma and death.
Clinical signs:
Not specified
Body weight:
Not specified
Gross pathology:
Dried cracked skin noted, persisting for 14 days.
Other findings:
See attachment.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The test substance tested has an acute dermal LD50 of < 5.0 g/kg.