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EC number: 825-246-3 | CAS number: 2098351-38-1
Species/strain: New Zealand White Rabbits Crl: KBL (NZW)
Number of animals: 3
Duration of exposure: 4 hours
Amount of substance: 0.5 g per test site
Type of dressing: semi-occlusive
Vehicle (moistening): none
First time of effects: animal no. 1: 24 hours after patch removalerythemagrade 1, animals no. 2 and no. 3: no effects observed
Last time of effects: animal no. 1: 48 hours after patch removalerythemagrade 1, animal no. 2 and no. 3: no effects observed
Reversibility of the observed effects: no effects observed
Method: OECD 404; EC 440/2008, Method B.4; OPPTS 870.2500; OPPTS 870.1000
Average Irritation Scores – (24, 48, 72-hour reading) – and Total Mean Value
Under the conditions of the present study, the single dermal application of the test item Coco iminodiglycinate, (Amines, N-C12-18-alkyltrimethylenedi-, reaction products with chloroacetic acid, sodium salts with CAS no 2098351-38-1) to three rabbits at a dose of 0.5 mL showed slight irritant but no corrosive effects in one animal which were fully reversible within up to 72 hours.
Neither mortalities nor significant clinical signs of toxicity were observed.
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