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EC number: 252-907-8 | CAS number: 36196-44-8
A sample of calcium thioglycolate trihydrate was assessed for its skin sensitisation potential using the mouse Local Lymph Node Assay. The assay determines the level of T lymphocyte proliferation in the lymph nodes draining the site of chemical application, by measuring the amount of radiolabelled thymidine incorporated into the dividing cells. The test substance was initially applied as 2.5%, 5% or 10% w/v preparations in propylene glycol. A further group was dosed with a 30% w/v preparation in propylene glycol.
Concentration of test substance (% w/v)
Number of lymph nodes assayed
Disintegrations per minute (dpm)
dpm per lymph node
0 (vehicle only)
The test substance was shown to have the capacity to cause skin sensitisation when applied as a 30% w/v preparation in propylene glycol.
In conclusion, calcium thioglycolate trihydrate is a skin sensitiser.
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