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EC number: 206-793-1 | CAS number: 375-73-5
The mutagenic potential of potassium perfluorobutane sulfonate was evaluated in the Bacterial Reverse Mutation Assay with Salmonella typhimurium strains TA 98, TA 100, TA 1535 and TA 1537 and Escherichia coli strain WP2uvrA in the presence and absence of metabolic activation (S9 mix; Aroclor 1254 -induced rat liver). The study was performed using potassium perfluororbutane sulfonate dissolved in DMSO at concentrations of 50, 100, 500, 1000 and 5000 ug/plate based on a range finding study. The first definitive mutation assay (B-1), using the plate incorporation method, was performed with the four S. typhimurium strains and with E. coli WP2uvrA. Treatment during B-1 was performed by adding either 500 uL deionized, distilled water or 500 uL of rat S-9 cofactor mix to tubes containing 2.0 mL top agar supplemented with 1X histidine-biotin or 1X tryptophan solution. Immediately after, 100 uL of strains TA 98, TA 100, TA 1535, TA 1537 or WP2uvrA were added followed by the appropriate test article dose or solvent. Positive controls were treated with 100 uL of the appropriate stock solution. Tubes were vortexed for 2 -3 seconds after and contents were evenly distributed over a Vogel-Bonner bottom agar plate. Plates were solified on a level surface, inverted, and then incubated at 37C for approximately 70.5 hours. Plates, starting with the highest test article concentration, were observed for the presence of precipitate. Plates with no precipitate were counted using an automatic colony counter (ARTEK Counter, Model 880) and those with precipitate were counted by hand. Three counts were taken by rotating the plate on the counter stage and the mediun count was entered into a validaed, Lotus 123 spreadsheet program. The background lawn was also evaluated. Based on the results of the study, potassium perfluorobutane sulfonate did not result in genotoxicity to Salmonella typhimurium strains TA 98, TA 100, TA 1535 and TA 1537 and Escherichia coli strain WP2uvrA in the presence or absence of exogenous metabolic activation at a dose of 50 -5000 ug/plate.
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