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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Experimental start date 13 December 2017 Experimental completion date 08 March 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient - HPLC Method)
Deviations:
no
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
Identity: 1,1-Dimethoxyethane
CAS number: 534-15-6
Batch number: 1710091650R
Purity: 99.91%
Physical state / Appearance: Clear liquid
Expiry date: 09 October 2019
Storage conditions: Refrigerator (2 - 8°C), under nitrogen, in the dark
Date received: 30 October 2017
Analytical method:
high-performance liquid chromatography
Type:
log Pow
Partition coefficient:
0.63
Temp.:
25 °C
pH:
7

HPLC Determination of Log10Pow for 1,1-Dimethoxyethane

Sample

Component

tr(minutes)

k'

log10k’

log10Pow

Standard Run A

Acetanilide

1.788

0.247

-0.608

1.00

(t0= 1.434 minutes)

Nitrobenzene

2.348

0.637

-0.196

1.90

 

Ethylbenzoate

3.389

1.363

0.135

2.60

 

Bromobenzene

4.479

2.123

0.327

3.00

 

Benzylbenzoate

6.096

3.251

0.512

4.00

 

DDT

35.528

23.775

1.376

6.20

Sample A

1,1-Dimethoxyethane

1.684

0.212

-0.675

0.63

(t0= 1.390 minutes)

Sample B

1,1-Dimethoxyethane

1.685

0.214

-0.670

0.64

(t0= 1.388 minutes)

Standard Run B

Acetanilide

1.785

0.247

-0.607

1.00

(t0= 1.431 minutes)

Nitrobenzene

2.346

0.639

-0.194

1.90

 

Ethylbenzoate

3.388

1.368

0.136

2.60

 

Bromobenzene

4.480

2.131

0.329

3.00

 

Benzylbenzoate

6.102

3.264

0.514

4.00

 

DDT

35.626

23.896

1.378

6.20

Linear regression (based on mean of standard runs A and B): log10Pow = 2.67log10k’ + 2.43

Conclusions:
The test item, 1,1-Dimethoxyethane, was found to have a log10Pow value of 0.63.
Executive summary:

The test item, 1,1-Dimethoxyethane, was found to have a log10Pow value of 0.63 using a procedure designed to be compatible with EC Method A.8 and OECD Method 117

Description of key information

The test item, 1,1-Dimethoxyethane, was found to have a log10Pow value of 0.63 using a procedure designed to be compatible with EC Method A.8 and OECD Method 117

Key value for chemical safety assessment

Log Kow (Log Pow):
0.63
at the temperature of:
25 °C

Additional information