2,2-bis[[(2-hexyl-1-oxodecyl)oxy]methyl]-1,3-propanediyl bis(2-hexyldecanoate)

Toxicity to aquatic algae and cyanobacteria

Link to relevant study record(s)

Reference

Endpoint:

toxicity to aquatic algae and cyanobacteria

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Justification for type of information:

see chapter 13 read-across justification

Reason / purpose for cross-reference:

read-across source

Key result

Duration:

72 h

Dose descriptor:

EL50

Effect conc.:

> 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Remarks:

(WAF)

Basis for effect:

growth rate

Key result

Duration:

72 h

Dose descriptor:

EL50

Effect conc.:

> 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Remarks:

(WAF)

Basis for effect:

biomass

Key result

Duration:

72 h

Dose descriptor:

NOELR

Effect conc.:

>= 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Remarks:

(WAF)

Basis for effect:

growth rate

Key result

Duration:

72 h

Dose descriptor:

NOELR

Effect conc.:

>= 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Remarks:

(WAF)

Basis for effect:

biomass

Details on results:

- Exponential growth in the control: yes

Table 1: Cell concentration (A680) in individual test cultures after 24, 48 and 72 h of exposure to the test material ((b) = Mean absorbance (A680))

Nominal concentration [mg/l]	Code	Cell concentration (A680)
		0 h (b)	24 h	48 h	72 h
Control	A B C D E	0.013 0.013 0.013 0.013 0.013	0.030 0.030 0.028 0.039 0.031	0.077 0.097 0.097 0.095 0.093	0.413 0.429 0.438 0.415 0.451
100	A B C	0.013 0.013 0.013	0.027 0.031 0.031	0.092 0.096 0.094	0.437 0.418 0.451

 

Table 2: Average specific growth rates between 0 and 72 h

Nominal concentration [mg/l]	Code	Average specific growth rate over 3 days/ d	Coefficient of correlation (R)	Inhibition [%]	Mean value [%]
Control	A B C D E	1.15 1.17 1.17 1.15 1.18	1.1	1.1 0.0 -0.6 0.9 -1.4	0.0
100	A B C	1.17 1.16 1.18	1.1	-0.5 0.7 -1.4	-0.4

 

Description of key information

No toxic effects to aquatic algae up to the limit of water solubility (< 0.05 mg/L).

Additional information

One study investigating the toxicity to aquatic algae and cyanobacteria offatty acids, C16-18 and C18-unsatd., tetraesters with pentaerythritol (CAS 68604-44-4) is available (Junghans, 2010). The limit study was performed according to OECD 201. The green algae Desmodesmus subspicatus was exposed to a nominal concentration of 100 mg/L. The test solution was prepared by adding the appropriate amount of test substance with subsequent stirring followed by filtration. No effect on growth rate and biomass of Desmodesmus subspicatus up to the limit of water solubility was observed resulting in an EL50 > 100 mg/L (nominal) and a NOELR of ≥ 100 mg/L (nominal).

Based on the results from the read-across substance, it can be concluded that 2,2-bis[[(2-hexyl-1-oxodecyl)oxy]methyl]-1,3-propanediyl bis(2-hexyldecanoate) will not exhibit effects to aquatic algae up to the limit of water solubility.

As it can be seen in the data matrix of the category justification in section 13 and the overall endpoint summary IUCLID 6.1, all reliable data in the category support the hazard assessment of each category member by showing a consistent pattern of results, no toxic effects were observed to aquatic algae or other aquatic organisms up to the limit of water solubility.